RETRACTED ARTICLE: Human mitochondrial genome flaws and risk of cancer
RETRACTED ARTICLE: Human mitochondrial genome flaws and risk of cancer
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DOI：
10.3109/19401736.2013.796520
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发表时间：
2014-09
影响因子：
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通讯作者：
Alok K. Singh;P. Pandey;M. Tewari;H. Pandey;H. S. Shukla
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文献类型：
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作者：
Alok K. Singh;P. Pandey;M. Tewari;H. Pandey;H. S. Shukla
摘要线粒体在细胞能量代谢中起重要作用。其中，这些功能包括自由基产生、控制细胞死亡、生长、发育、信号从线粒体到细胞核和细胞核到线粒体的整合以及各种代谢途径。给定突变的生物学影响可能会有所不同，这取决于突变的性质和细胞携带的突变mtDNA的比例。癌前病变中mtDNA突变的鉴定支持它们对细胞转化和癌症进展的早期贡献。在转化细胞中引入mtDNA突变与增加的ROS产生和肿瘤生长相关。研究表明，线粒体DNA的增加和改变在癌症的发展中起作用，但需要进一步的工作来确定特定线粒体突变在癌症和疾病进展中的功能意义。本文简要综述了该领域的最新进展。
Abstract Mitochondria perform significant roles in cellular energy metabolism. Among others, these functions include free radicals generation, control of cell death, growth, development, integration of signals from mitochondria to nucleus and nucleus to mitochondria, and various metabolic pathways. The biological impact of a given mutation may vary, depending on the nature of the mutation and the proportion of mutant mtDNAs carried by the cell. Identification of mtDNA mutations in precancerous lesions supports their early contribution to cell transformation and cancer progression. Introduction of mtDNA mutations in transformed cells has been associated with increased ROS production and tumor growth. Studies reveal that increased and altered mtDNA plays a role in the development of cancer but further work is required to establish the functional significance of specific mitochondrial mutations in cancer and disease progression. This review briefly summarizes the recent progress in this field.