Chronic constriction injury reduces cannabinoid receptor 1 activity in the rostral anterior cingulate cortex of mice.
Chronic constriction injury reduces cannabinoid receptor 1 activity in the rostral anterior cingulate cortex of mice.
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DOI：
10.1016/j.brainres.2010.03.105
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发表时间：
2010-06-21
期刊：
影响因子：
2.9
通讯作者：
Dewey WL
中科院分区：
文献类型：
--
作者：
Hoot MR;Sim-Selley LJ;Poklis JL;Abdullah RA;Scoggins KL;Selley DE;Dewey WL
The present studies examined the effect of chronic neuropathic pain on cannabinoid receptor density and receptor-mediated G-protein activity within supraspinal brain areas involved in pain processing and modulation in mice. Chronic constriction injury (CCI) produced a significant decrease in WIN 55, 212-2 -stimulated [35S]GTPγS binding in membranes prepared from the rostral anterior cingulate cortex (rACC) of CCI mice when compared to sham operated controls. Saturation binding with [3H]SR 141716A in membranes of the rACC showed no significant differences in binding between CCI and sham mice. Analysis of levels of the endocannabinoids anandamide (AEA) or 2-arachidonoylglycerol (2-AG) in the rACC following CCI showed no significant differences between CCI and sham mice. These data suggest that CCI produced desensitization of the cannabinoid 1 receptor in the rACC in the absence of an overall decrease in cannabinoid 1 receptor density or change in levels of AEA or 2-AG. These data are the first to show alterations in cannabinoid receptor function in the rostral anterior cingulate cortex in response to a model of neuropathic pain.
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DOI：
10.1196/annals.1432.037
发表时间：
2008-01-01
期刊：
DRUG ADDICTION: RESEARCH FRONTIERS AND TREATMENT ADVANCES
影响因子：
--
作者：
Brusco, A.;Tagliaferro, P. A.;Onaivi, E. S.
通讯作者：
Onaivi, E. S.
影响因子：
2.5
作者：
Herzberg, U;Eliav, E;Kopin, IJ
通讯作者：
Kopin, IJ
影响因子：
2.5
作者：
Kuo, Chung-Chih;Chiou, Ruei-Jen;Yen, Chen-Tung
通讯作者：
Yen, Chen-Tung
影响因子：
3.4
作者：
Kulkarni, B;Bentley, DE;Jones, AKP
通讯作者：
Jones, AKP
头侧前扣带皮层中的 NMDA NR2A 和 NR2B 受体有助于雄性大鼠与疼痛相关的厌恶。
影响因子：
7.4
作者：
Li TT;Ren WH;Xiao X;Nan J;Cheng LZ;Zhang XH;Zhao ZQ;Zhang YQ
通讯作者：
Zhang YQ