Hepatectomy for hepatocellular carcinoma larger than 10cm: preoperative risk stratification to prevent futile surgery
Hepatectomy for hepatocellular carcinoma larger than 10cm: preoperative risk stratification to prevent futile surgery
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DOI：
10.1111/hpb.12416
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发表时间：
2015-07-01
期刊：
影响因子：
2.9
通讯作者：
Azoulay, Daniel
中科院分区：
文献类型：
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作者：
Lim, Chetana;Compagnon, Philippe;Azoulay, Daniel
目的：对于巨大（10 cm）肝癌患者，适当的患者选择对于获得良好的预后和避免无效的手术是重要的。本研究的目的是确定无效结果的独立预测因素，定义为手术后3个月内或1年内从肝切除术后早期复发的巨大hepatocyto.MethodsThe 149例巨大HCCs在1995-2012年期间接受切除术的结果进行了分析。结果3个月死亡率（18.1%）的独立预测因素为：总胆红素> 34 mol/l [P=0.0443; OR 16.470];血小板计数> 1000 μ g/ml [P= 0.00000];
ObjectivesAppropriate patient selection is important to achieving good outcomes and obviating futile surgery in patients with huge (10cm) hepatocellular carcinoma (HCC). The aim of this study was to identify independent predictors of futile outcomes, defined as death within 3months of surgery or within 1year from early recurrence following hepatectomy for huge HCC.MethodsThe outcomes of 149 patients with huge HCCs who underwent resection during 1995-2012 were analysed. Multivariate logistic regression analysis was performed to identify preoperative independent predictors of futility.ResultsIndependent predictors of 3-month mortality (18.1%) were: total bilirubin level >34mol/l [P=0.0443; odds ratio (OR) 16.470]; platelet count of