A comparison of triclosan and stannous fluoride toothpastes for inhibition of plaque regrowth. A crossover study designed to assess carry over.
A comparison of triclosan and stannous fluoride toothpastes for inhibition of plaque regrowth. A crossover study designed to assess carry over.
复制标题
三氯生牙膏和氟化亚锡牙膏抑制牙菌斑再生的比较。
DOI：
10.1111/j.1600-051x.1997.tb00486.x
复制
发表时间：
1997
影响因子：
6.7
通讯作者：
J. Faulkner
中科院分区：
文献类型：
--
作者：
A. Binney;M. Addy;J. Owens;J. Faulkner
一些三氯生和氟化亚锡牙膏在家庭使用研究中显示出有效减少牙菌斑，尤其是牙龈炎。很少有比较这些产品的化学菌斑抑制作用脱离刷牙的不确定变量。本研究是一项随机、单盲、交叉比较4种产品的研究，采用4天斑块再生设计，平衡了残余效应，涉及12名健康的有齿受试者。测试试剂为氟化亚锡牙膏、三氯生/共聚物牙膏、三氯生/柠檬酸锌牙膏和水。在每个研究阶段的第1天，使受试者无斑块。在接下来的4天里，每名受试者暂停正常的牙齿清洁，并在监督下每天用分配的治疗冲洗2次，持续60秒。在第5天，通过指数对斑块进行评分。每个治疗期后，仅用水刷牙2 1/2天的洗脱期。在氟化亚锡和三氯生/柠檬酸锌治疗后进行正常冲洗后，进行4天的假治疗期，包括每日2次用水冲洗（不刷牙），总共6个治疗期。该设计允许分析一阶残留。意向治疗分析显示，所有牙膏都比水更有效，但活性治疗之间没有差异。符合方案分析给出了基本相似的结果，除了有利于三氯生/柠檬酸锌牙膏的菌斑差异没有达到显著性。没有证据表明氟化亚锡或三氯生/柠檬酸锌牙膏存在一级残留效应。与其他研究一致，氟化亚锡和三氯生似乎可以配制成牙膏载体，以提供牙菌斑抑制作用。
Some triclosan and stannous fluoride toothpastes have been shown effective in reducing plaque and more particularly gingivitis in home use studies. There have been few comparisons of such products for their chemical plaque inhibitory action divorced from the indeterminate variable of toothbrushing. This study was a randomised, single-blind, cross-over comparison of 4 products, in a 4-day plaque regrowth design, balanced for residual effects and involving 12 healthy dentate subjects. The test agents were a stannous fluoride toothpaste, a triclosan/copolymer toothpaste, a triclosan/zinc citrate toothpaste and water. On day 1 of each study period, subjects were rendered plaque free. For the following 4 days, each subject suspended normal toothcleaning and rinsed 2 x daily with the allocated treatment for 60 s under supervision. On day 5, plaque was scored by index. Washout periods of 2 1/2 days brushing with water alone, followed each treatment period. Pseudo treatment periods of 4 days, involving 2 x daily rinsing with water in the absence of toothbrushing, followed the normal washouts after the stannous fluoride and triclosan/zinc citrate treatments, giving a total of 6 treatment periods. This design permitted analyses for 1st-order-carry-over. Intention to treat analyses revealed all toothpastes were more effective than water but that there were no differences between the active treatments. Per protocol analysis gave essentially similar findings except that the difference in plaque in favour of the triclosan/zinc citrate toothpaste over water did not reach significance. There was no evidence of 1st-order-carry-over effects for the stannous fluoride or triclosan/zinc citrate toothpastes. Consistent with other studies it appears that stannous fluoride and triclosan can be formulated into toothpaste vehicles to provide plaque inhibitory effects.