Association of PLA2G7 polymorphisms with carotid atherosclerosis in hypertensive Japanese
Association of PLA2G7 polymorphisms with carotid atherosclerosis in hypertensive Japanese
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DOI：
10.1038/hr.2009.151
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发表时间：
2009-12-01
影响因子：
5.4
通讯作者：
Kawano, Yuhei
中科院分区：
文献类型：
--
作者：
Miwa, Yoshikazu;Kamide, Kei;Kawano, Yuhei
虽然血浆血小板活化因子乙酰水解酶（pPAF-AH）基因（PLA 2G 7）多态性与动脉粥样硬化性疾病有关，但其在高血压患者中的作用尚未得到很好的研究。因此，我们对V279 F（一种常见于日本人的功能丧失突变）和I198 T和A379 V（常见于高加索人）进行基因分型，并在733例接受治疗的日本高血压患者中研究（1）频率的种族差异和（2）这些变异与颈动脉斑块患病率的相关性。V279 F（V等位基因75.1%，F等位基因24.9%）在高血压患者中的分布与日本健康人群相似，而I198 T（I等位基因71.7%，T等位基因28.3%）和A379 V（A等位基因84.7%，V等位基因15.3%）的等位基因频率与白种人有显著差异。此外，V279 F和I198 T表现出很强的连锁不平衡（D '= 1.0，r（2）=0.89）。除女性I198 T基因型的血压水平外，其他基因型的表型均无差异。颈动脉斑块是显着更流行的主题与279 F和198 T比野生型的男性，但不是女性，而A379 V并没有影响it. In多变量Logistic回归分析，279 F和198 T被检测为一个独立的危险因素，即使在调整其他动脉粥样硬化的危险因素在男性。两者合计，我们的数据表明，种族差异和可能参与的基因多态性PLA 2G 7的颈动脉粥样硬化的患病率在高血压的日本，特别是在男性。高血压研究（2009）32，1112-1118; doi：10.1038/hr.2009.151; 2009年9月18日在线发表
Although the plasma platelet-activating factor-acetylhydrolase (pPAF-AH) gene (PLA2G7) polymorphisms are reportedly associated with atherosclerotic diseases, their effects in hypertensive patients have not been well examined. Thus, we genotyped V279F, a loss-of-function mutation commonly seen in the Japanese, and I198T and A379V commonly seen in Caucasians, and investigated the (1) ethnic differences in the frequencies and (2) association of these variants with prevalence of carotid plaque in 733 treated hypertensive Japanese patients. The distribution of V279F (V allele 75.1% and F allele 24.9%) in hypertensive patients was similar to that previously reported in the healthy Japanese; however, allele frequencies of I198T (I allele 71.7% and T allele 28.3%) and A379V (A allele 84.7% and V allele 15.3%) were markedly different from those reported in Caucasians. In addition, V279F and I198T showed a strong linkage disequilibrium (D'=1.0, r(2)=0.89). The phenotypes showed no difference among genotypes for each polymorphism except for the blood pressure level in I198T in women. Carotid plaque was significantly more prevalent in subjects with 279F and 198T than in those with the wild type among men but not women, whereas A379V did not affect it. In multivariate logistic regression analyses, 279F and 198T were detected as an independent risk factor even after adjustments for other atherosclerotic risk factors in men. Taken together, our data suggest an ethnic difference and the possible involvement of genetic polymorphisms of PLA2G7 in the prevalence of carotid atherosclerosis in the hypertensive Japanese, especially in men. Hypertension Research (2009) 32, 1112-1118; doi: 10.1038/hr.2009.151; published online 18 September 2009