Optical fiber probe for biomedical Raman spectroscopy
Optical fiber probe for biomedical Raman spectroscopy
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DOI：
10.1364/ao.43.000542
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发表时间：
2004-01-20
期刊：
影响因子：
1.9
通讯作者：
Feld, MS
中科院分区：
文献类型：
--
作者：
Motz, JT;Hunter, M;Feld, MS
体外实验已经证明了拉曼光谱诊断多种疾病的能力。最近用光纤探针进行的体内研究很有希望，但通常仅限于容易接近的器官，通常需要相对较长的收集时间。我们实施了一种光学设计策略，通过表征组织的拉曼分布来充分利用系统吞吐量。该方案优化了采集效率，最小化了噪声，并产生了小直径，高效率的拉曼探头，能够在1秒内收集高质量的数据。通过组织模型和几种体外组织类型的模拟和实验测试了性能，表明这种新设计可以推动拉曼光谱作为临床实用技术。(C) 2004美国光学学会。
In vitro experiments have demonstrated the ability of Raman spectroscopy to diagnose a wide variety of diseases. Recent in vivo investigations performed with optical fiber probes were promising but generally limited to easily accessible organs, often requiring relatively long collection times. We have implemented an optical design strategy to utilize system throughput fully by characterizing the Raman distribution from tissue. This scheme optimizes collection efficiency, minimizes noise, and has resulted in small-diameter, highly efficient Raman probes that are capable of collecting high-quality data in 1 s. Performance has been tested through simulations and experiments with tissue models and several in vitro tissue types, demonstrating that this new design can advance Raman spectroscopy as a clinically practical technique. (C) 2004 Optical Society of America.