Nonlinear Elastic and Inelastic Properties of Cells.
Nonlinear Elastic and Inelastic Properties of Cells.
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DOI：
10.1115/1.4046863
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发表时间：
2020-04
期刊：
影响因子：
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通讯作者：
Wonyeong Jung;Jing Li;Ovijit Chaudhuri;Taeyoon Kim
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文献类型：
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作者：
Wonyeong Jung;Jing Li;Ovijit Chaudhuri;Taeyoon Kim
机械力在形态发生、胞质分裂和迁移等多种生理过程中起着重要作用。因此，为了阐明这些生理过程背后的机制，了解细胞如何变形和对外部机械刺激做出反应至关重要。近几十年来，细胞的力学性能已被广泛研究，使用不同的测量技术。大量的实验研究表明，细胞远非线性弹性材料。细胞表现出各种各样的非线性弹性和非弹性性质。已知细胞的这种复杂性质来自细胞组分的独特机械特性。在这篇综述中，我们介绍了主要的细胞成分，在很大程度上管理细胞的力学性能，并提供了几个实验技术用于流变测量细胞力学的简要解释。然后，我们讨论了代表性的非线性弹性和非弹性性能的细胞。最后，连续和离散计算模型的细胞力学，模型的非线性弹性和非弹性性能的细胞，将被描述。
Mechanical forces play an important role in various physiological processes, such as morphogenesis, cytokinesis, and migration. Thus, in order to illuminate mechanisms underlying these physiological processes, it is crucial to understand how cells deform and respond to external mechanical stimuli. During recent decades, the mechanical properties of cells have been studied extensively using diverse measurement techniques. A number of experimental studies have shown that cells are far from linear elastic materials. Cells exhibit a wide variety of nonlinear elastic and inelastic properties. Such complicated properties of cells are known to emerge from unique mechanical characteristics of cellular components. In this review, we introduce major cellular components that largely govern cell mechanical properties and provide brief explanations of several experimental techniques used for rheological measurements of cell mechanics. Then, we discuss the representative nonlinear elastic and inelastic properties of cells. Finally, continuum and discrete computational models of cell mechanics, which model both nonlinear elastic and inelastic properties of cells, will be described.