Lesions of the posterior bed nucleus of the stria terminalis eliminate opposite-sex odor preference and delay copulation in male Syrian hamsters: role of odor volatility and sexual experience
Lesions of the posterior bed nucleus of the stria terminalis eliminate opposite-sex odor preference and delay copulation in male Syrian hamsters: role of odor volatility and sexual experience
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DOI：
10.1111/j.1460-9568.2010.07277.x
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发表时间：
2010-08-01
影响因子：
3.4
通讯作者：
Petrulis, Aras
中科院分区：
文献类型：
--
作者：
Been, Laura E.;Petrulis, Aras
在叙利亚仓鼠（Mesocricetus auratus），生殖行为的表达需要社会气味的感知。对这些气味的行为反应由腹侧前脑核团网络介导，包括终纹后床核（pBNST）。先前的研究已经测试了pBNST在生殖行为中的作用，但是在这些研究中使用大的纤维损伤性病变使得难以将病变后的缺陷具体归因于pBNST。因此，目前的研究使用离散的，兴奋性毒性病变的pBNST测试的作用，pBNST在异性气味偏好和交配行为的性幼稚和性经验丰富的男性。病变的pBNST减少性幼稚男性的挥发性女性气味的调查，导致消除异性气味偏好。这种偏好的消除不是由于感觉缺陷，因为pBNST病变的男性能够区分气味。然而，当受试者在pBNST病变前获得性经验时，他们对挥发性异性气味的偏好在病变后保持不变。同样地，当性经验丰富的受试者被允许在偏好测试中接触社会气味时，pBNST的病变减少了男性对女性气味的调查，但并没有消除对异性气味的偏好，无论性经验如何。最后，病变的pBNST延迟交配序列的性幼稚，但没有性经验，男性，使他们需要更长的时间来安装，导入，射精和显示长的导入。总之，这些结果表明，pBNST起着独特的和关键的作用，在男性生殖行为的食欲和消费方面。
In Syrian hamsters (Mesocricetus auratus), the expression of reproductive behavior requires the perception of social odors. The behavioral response to these odors is mediated by a network of ventral forebrain nuclei, including the posterior bed nucleus of the stria terminalis (pBNST). Previous studies have tested the role of the pBNST in reproductive behavior, but the use of large, fiber-damaging lesions in these studies make it difficult to attribute post-lesion deficits to the pBNST specifically. Thus, the current study used discrete, excitotoxic lesions of the pBNST to test the role of the pBNST in opposite-sex odor preference and copulatory behavior in both sexually-naive and sexually-experienced males. Lesions of the pBNST decreased sexually-naive males' investigation of volatile female odors, resulting in an elimination of opposite-sex odor preference. This elimination of preference was not due to a sensory deficit, as males with pBNST lesions were able to discriminate between odors. When, however, subjects were given sexual experience prior to pBNST lesions, their preference for volatile opposite-sex odors remained intact post-lesion. Similarly, when sexually-naive or sexually-experienced subjects were allowed to contact the social odors during the preference test, lesions of the pBNST decreased males' investigation of female odors but did not eliminate preference for opposite-sex odors, regardless of sexual experience. Finally, lesions of the pBNST delayed the copulatory sequence in sexually-naive, but not sexually-experienced, males such that they took longer to mount, intromit, ejaculate and display long intromissions. Together, these results demonstrate that the pBNST plays a unique and critical role in both appetitive and consummatory aspects of male reproductive behaviors.