Chloride and sodium fluxes across rat tracheal epithelium in health and disease.
Chloride and sodium fluxes across rat tracheal epithelium in health and disease.
复制标题
健康和疾病状态下，氯离子和钠离子穿过大鼠气管上皮。
DOI：
10.1159/000194514
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
G. Melville
中科院分区：
文献类型：
--
作者：
G. Melville
在正常和支气管炎大鼠的气管上皮细胞的跨气管电位差和钠和氯通量进行了评估。结果表明：（1）支气管炎动物的跨气管电位差较低，（2）Na+和Cl-向管腔的净移动增加，（3）在体内和体外的跨气管电位差为4 ~ 15 mV，管腔对粘膜下层呈负电位。认为睫状体间液层的变化与离子的净运动、微绒毛细胞的数量以及这些离子的胆碱能分泌作用密切相关。
Transtracheal potential differences and sodium and chloride fluxes in the tracheal epithelium were assessed in normal and bronchitic rats. The results showed that (1) the potential difference was lower in animals with bronchitis; (2) net movement of Na+and Cl-towards the lumen increased in bronchitis, and (3) the transtracheal potential difference in vivo and in vitro ranged from 4 to 15 mV with the lumen negative to submucosa. It is postulated that changes in the interciliary fluid layer is closely related to the net movement of ions, the number of microvilli-bearing cells and the cholinergic secreting effects of these ions.