Relevant modulation by ferrous ions of N-methyl-D-aspartate receptors in ischemic brain injuries.
Relevant modulation by ferrous ions of N-methyl-D-aspartate receptors in ischemic brain injuries.
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DOI：
10.2174/1567202043361910
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发表时间：
2004-11
影响因子：
2.1
通讯作者：
N. Nakamichi;H. Oikawa;Y. Kambe;Y. Yoneda
中科院分区：
文献类型：
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作者：
N. Nakamichi;H. Oikawa;Y. Kambe;Y. Yoneda
N-甲基-D-天冬氨酸（NMDA）受体的激活将诱导跨细胞膜的可渗透Ca 2+离子的离子通道的快速打开，随后是细胞质中游离Ca 2+离子浓度的增加，以及随后从细胞质到细胞核的信号级联，用于巩固中枢神经系统中由L-谷氨酸携带的瞬时细胞外信号。神经元可塑性和细胞死亡都已被证明涉及细胞内游离Ca 2+离子通过这种受体操作的阳离子通道在大脑中。另一方面，铁在大脑中也很丰富，在维持细胞完整性和功能的机制中起着重要作用。亚铁离子被认为通过在缺血性脑损伤中产生活性氧来参与神经元细胞死亡，例如，而亚铁离子而不是三价铁离子显示出阻断Ca 2+离子穿过培养的神经元中的NMDA受体通道的流入。在这篇综述文章中，我们将总结铁和NMDA受体通道在脑缺血神经细胞死亡相关机制中的可能关系。
Activation of the N-methyl-D-aspartate (NMDA) receptor would induce rapid opening of an ion channel permeable to Ca2+ ions across cell membranes, followed by an increase in the concentration of free Ca2+ ions in the cytoplasm and subsequent signaling cascade from the cytoplasm to the nucleus for consolidation of a transient extracellular signal carried by L-glutamate in the central nervous system. Both neuronal plasticity and cell death have been shown to involve intracellular free Ca2+ ions incorporated through this receptor-operated cation channel in the brain. On the other hand, iron is also abundant in the brain, with an essential role in mechanisms underlying maintenance of cellular integrity and function. Ferrous ions are believed to participate in neuronal cell death through generation of reactive oxygen species in ischemic brain injuries, for instance, while ferrous but not ferric ions are shown to block the influx of Ca2+ ions across NMDA receptor channels in cultured neurons. In this review article, we will summarize the possible relationship between iron and NMDA receptor channels in mechanisms associated with neuronal cell death in brains with ischemia.