Abdominal pain in patients with resectable pancreatic cancer with reference to clinicopathologic findings
Abdominal pain in patients with resectable pancreatic cancer with reference to clinicopathologic findings
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DOI：
10.1097/00006676-200104000-00009
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发表时间：
2001-04-01
期刊：
影响因子：
2.9
通讯作者：
Sakamoto, M
中科院分区：
文献类型：
--
作者：
Okusaka, T;Okada, S;Sakamoto, M
腹痛和/或背痛是胰腺癌患者最常见的症状之一。然而，疼痛的原因和疼痛患者的临床病理特征尚未完全阐明。我们回顾分析了95例可切除胰腺癌患者术前腹痛和/或背痛的相关因素。胰腺肿瘤大小、胰腺内神经侵犯、胰腺前包膜侵犯和淋巴结转移被确定为与疼痛相关的变量。胰腺肿瘤大小、胰腺前包膜侵犯和淋巴结转移也是与疼痛强度显著相关的变量。生存期也与疼痛强度相关：无疼痛患者的中位生存期为29个月，轻度疼痛患者为19个月，重度疼痛患者为9个月，需要镇痛剂。在可切除的胰腺癌患者中，较大的胰腺肿瘤、侵犯胰腺内神经和侵犯胰腺前包膜可能会导致腹痛和/或背痛。这项研究还表明，疼痛强度作为可切除胰腺癌患者的预后因素具有临床意义。
Abdominal and/or back pain is one of the most common symptoms in patients with pancreatic cancer. However, the cause of the pain and the clinicopathologic features of patients with pain have not been fully elucidated. We retrospectively determined the factors related to preoperative abdominal and/or back pain in 95 patients with resectable pancreatic cancer. Pancreatic tumor size, invasion of the intrapancreatic nerves, invasion of the anterior pancreatic capsule, and lymph node metastasis were determined to be variables related to the pain. Pancreatic tumor size, invasion of anterior pancreatic capsule, and lymph node metastasis were also variables significantly correlating to pain intensity. Survival also correlated with pain intensity: the median survival periods were 29 months in patients without pain, 19 months in those with mild pain, and 9 months in those with severe pain who required analgesics. Larger pancreatic tumors, invasion of the intrapancreatic nerves, and invasion of the anterior pancreatic capsule may cause abdominal and/or back pain in patients with resectable pancreatic cancer. This study also suggests clinical implications of the pain intensity as a prognostic factor in patients with resectable pancreatic cancer.