Role of fear in mediating shuttle escape learning deficit produced by inescapable shock.
Role of fear in mediating shuttle escape learning deficit produced by inescapable shock.
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DOI：
10.1037//0097-7403.16.2.137
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发表时间：
1990-04
期刊：
影响因子：
--
通讯作者：
S. Maier
中科院分区：
文献类型：
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作者：
S. Maier
在大鼠中研究了先前不可避免的休克（IS）产生的穿梭箱逃逸缺陷与通过冷冻评估的穿梭箱测试期间的恐惧之间的关系。 IS 大鼠的逃生能力较差，并且在穿梭箱中接受电击之前和之后都比逃脱电击的受试者或对照组更害怕。然而，恐惧和较差的逃避表现并不与旨在调节恐惧程度和逃避缺陷发生的变量的操纵相一致。 IS 和测试之间的 72 小时间隔消除了逃生缺陷，但并没有减少震前冻结。测试前的地西泮可以减少穿梭机中的休克前和休克后的恐惧，但对逃生缺陷没有影响。纳曲酮对恐惧没有影响，但消除了逃避缺陷。这种结果的独立性表明，穿梭机逃逸缺陷并不是由 IS 对象的高度恐惧引起的。
The relation between the shuttlebox escape deficit produced by prior inescapable shock (IS) and fear during shuttlebox testing as assessed by freezing was investigated in rats. IS rats learned to escape poorly and were more fearful than either escapably shocked subjects or controls, both before and after receiving shock in the shuttlebox. However, fear and poor escape performance did not covary with the manipulation of variables designed to modulate the amount of fear and the occurrence of the escape deficit. A 72-hr interval between IS and testing eliminated the escape deficit but did not reduce preshock freezing. Diazepam before testing reduced both preshock and postshock fear in the shuttlebox but had no effect on the escape deficit. Naltrexone had no effect on fear but eliminated the escape deficit. This independence of outcomes suggests that the shuttlebox escape deficit is not caused by high levels of fear in IS subjects.