Evolutionary determinants of cancer.
Evolutionary determinants of cancer.
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DOI：
10.1158/2159-8290.cd-15-0439
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发表时间：
2015-08
期刊：
影响因子：
28.2
通讯作者：
Greaves M
中科院分区：
文献类型：
--
作者：
Greaves M
“生物学中没有什么是有意义的，除非根据进化论。”Dobzhansky，1973我们对癌症的理解正在通过在进化框架内探索克隆多样性，耐药性和因果关系而改变。晚期癌症的治疗弹性是其作为复杂，动态和适应性生态系统的特征的结果，这些生态系统产生鲁棒性，并由遗传多样性和表观遗传可塑性支撑。自我更新细胞突变驱动逃逸的风险是多细胞生物固有的，但受到多种限制的抵消，促进了物种的复杂性和寿命的增加。但我们自己却通过迅速升级的内在风险打破了这一历史叙事。进化原理阐明了这些挑战，并为探索更有效的控制提供了新的途径。
‘Nothing in biology makes sense except in the light of evolution’ Th. Dobzhansky, 1973 Our understanding of cancer is being transformed by exploring clonal diversity, drug resistance and causation within an evolutionary framework. The therapeutic resilience of advanced cancer is a consequence of its character as complex, dynamic and adaptive ecosystem engendering robustness, underpinned by genetic diversity and epigenetic plasticity. The risk of mutation-driven escape by self-renewing cells is intrinsic to multicellularity but is countered by multiple restraints facilitating increasing complexity and longevity of species. But our own has disrupted this historical narrative by rapidly escalating intrinsic risk. Evolutionary principles illuminate these challenges and provide new avenues to explore for more effective control.