SERUM SEX HORMONE-BINDING GLOBULIN DURING PUBERTY IN GIRLS AND IN DIFFERENT TYPES OF ADOLESCENT MENSTRUAL CYCLES
SERUM SEX HORMONE-BINDING GLOBULIN DURING PUBERTY IN GIRLS AND IN DIFFERENT TYPES OF ADOLESCENT MENSTRUAL CYCLES
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DOI：
10.1530/acta.0.1070413
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发表时间：
1984-01-01
期刊：
影响因子：
--
通讯作者：
VIHKO, R
中科院分区：
文献类型：
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作者：
APTER, D;BOLTON, NJ;VIHKO, R
血清性激素结合球蛋白（SHBG）浓度测定的免疫放射分析，作为青春期女孩的纵向研究的一部分，并与年龄，青春期阶段，初潮年龄，体重，月经周期的性质和性类固醇的血清浓度。SHBG从8-10岁时的77 nmol/l下降到15岁后的约50 nmol/l，下降缓慢但非常显著。青春期血清SHBG浓度与雄烯二酮、睾酮呈弱负相关。SHBG和测量的参数之间最密切的关联是与月经前期和月经后期女孩的体重和体脂百分比呈负相关，即使在通过计算偏相关系数来解释年龄的影响之后。与初潮较晚的女孩相比，初潮较早的女孩（13.0岁之前）在10.0-15.9岁时SHBG较低，但雌二醇血清浓度较高。在有排卵的月经周期中，发现从周期的早期到晚期SHBG显著增加，而在无排卵周期中没有变化。在月经周期的后期采集的样本中，血清SHBG浓度与雌二醇和孕酮浓度呈正相关。鉴于血清SHBG和性类固醇浓度之间的弱关系，以及SHBG，体重和体脂百分比之间的强关系，在青春期SHBG水平的调节中必须考虑类固醇以外的因素。
Serum sex hormone binding globulin (SHBG) concentrations were measured by an immunoradiometric assay, as part of a longitudinal study of puberty in girls, and were related to age, pubertal stage, age at menarche, weight, nature of the menstrual cycle and serum concentrations of sex steroids. A slow but very significant decrease was seen in SHBG from 77 nmol/l at 8-10 yr of age to about 50 nmol/l after 15 yr of age. Serum SHBG concentrations showed weak negative correlations with those of androstendione and testosterone during puberty. The closest associations found between SHBG and the parameters measured were negative correlations with weight and body fat percentage in both pre-menarcheal and post-menarcheal girls, even after the effect of age was accounted for by calculating partial correlation coefficients. Girls who experienced early menarche (before 13.0 yr) had lower SHBG but higher estradiol serum concentrations at 10.0-15.9 yr of age compared to girls with later menarche. In ovulatory menstrual cycles, a significant increase in SHBG was found from the early to the late part of the cycle, whereas no changes took place in anovulatory cycles. Serum concentrations of SHBG showed positive correlations with those of estradiol and progesterone in specimens taken in the late part of the cycle. In view of the weak relationships between serum SHBG and sex steroid concentrations, and the strong relationships between SHBG, weight and body fat percentage, factors other than steroids have to be considered in the regulation of SHBG levels during puberty.