Averting a malaria disaster: will insecticide resistance derail malaria control?
Averting a malaria disaster: will insecticide resistance derail malaria control?
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DOI：
10.1016/s0140-6736(15)00417-1
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发表时间：
2016-04-23
期刊：
影响因子：
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通讯作者：
Hamon N
中科院分区：
文献类型：
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作者：
Hemingway J;Ranson H;Magill A;Kolaczinski J;Fornadel C;Gimnig J;Coetzee M;Simard F;Roch DK;Hinzoumbe CK;Pickett J;Schellenberg D;Gething P;Hoppé M;Hamon N
2015年世界疟疾日突出了在制定预防(疫苗和杀虫剂)和治疗(单剂药物)新方法方面取得的进展。然而，不断增加的药物和杀虫剂耐药性威胁着现有方法取得的成功。杀虫剂抗药性降低了最常用的拟除虫菊酯类杀虫剂的药效。这种药效的下降增加了蚊子的存活率，这是疟疾发病率和死亡率上升的前奏。尽管进行了密集的研究工作，但新的杀虫剂至少在5年内不会进入市场。如果没有有效的蚊子控制，就不可能消除疟疾。因此，为了应对耐药性的威胁，主要利益攸关方需要迅速采取多方面的方法，包括降低将新的耐药性管理方法推向市场的成本，以及精简相关的发展、政策和实施途径，以应对这场迫在眉睫的公共卫生灾难。
World Malaria Day 2015 highlighted the progress made in the development of new methods of prevention (vaccines and insecticides) and treatment (single dose drugs) of the disease. However, increasing drug and insecticide resistance threatens the successes made with existing methods. Insecticide resistance has decreased the efficacy of the most commonly used insecticide class of pyrethroids. This decreased efficacy has increased mosquito survival, which is a prelude to rising incidence of malaria and fatalities. Despite intensive research efforts, new insecticides will not reach the market for at least 5 years. Elimination of malaria is not possible without effective mosquito control. Therefore, to combat the threat of resistance, key stakeholders need to rapidly embrace a multifaceted approach including a reduction in the cost of bringing new resistance management methods to market and the streamlining of associated development, policy, and implementation pathways to counter this looming public health catastrophe.