Paradoxical sleep deprivation impairs acquisition, consolidation, and retrieval of a discriminative avoidance task in rats
Paradoxical sleep deprivation impairs acquisition, consolidation, and retrieval of a discriminative avoidance task in rats
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DOI：
10.1016/j.nlm.2008.07.013
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发表时间：
2008-11-01
影响因子：
2.7
通讯作者：
Tufik, Sergio
中科院分区：
文献类型：
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作者：
Alvarenga, Tathiana A.;Patti, Camilla L.;Tufik, Sergio
本研究的目的是探讨矛盾睡眠剥夺（PSD） 96小时对大鼠学习/记忆过程的影响，这些大鼠接受了加迷宫歧视性回避任务（PMDAT）。同时评估学习。记忆，焦虑和运动功能。实验分为四个阶段：(1)训练后和测试前PSD；(2)训练后或测试前PSD:(3)训练前PSD或训练前矛盾睡眠（PS）反弹（24 h）和(4)测试前PSD反弹。在实验1中，训练后和测试前PSD诱导记忆缺陷、焦虑样行为和运动活动增加。在实验二中，训练后剥夺ps组和测试前剥夺ps组均表现出记忆缺陷。然而，只有测试前剥夺ps的动物表现出焦虑样行为和运动活动增加。在实验三中，预训练剥夺ps的大鼠表现出学习和记忆缺陷，焦虑样行为和运动活动增加。PSD后24小时的睡眠恢复期消除了学习和记忆缺陷，但没有消除焦虑和运动改变。最后，睡眠反弹不影响习得（实验三）和检索（实验四）。这项研究强调了矛盾睡眠（而不是睡眠反弹）在学习和记忆形成的所有阶段中的关键作用。此外，这表明PSD对习得和巩固的影响似乎与该过程引起的其他行为改变无关。(C) 2008爱思唯尔公司版权所有。
The aim of the present study was to investigate the effects of paradoxical sleep deprivation (PSD) for 96 h on the learning/memory processes in rats submitted to the plus-maze discriminative avoidance task (PMDAT). which simultaneously evaluates learning. memory, anxiety and motor function. Four experiments were performed in which rats were submitted to: (1) post-training and pre-test PSD; (2) post-training or pre-test PSD: (3) pre-training PSD or pre-training paradoxical sleep (PS) rebound (24 h) and (4) pre-test PSD rebound. Concerning Experiment 1, post-training and pre-test PSD induced memory deficits, an anxiolytic-like behavior and an increase in locomotor activity. In Experiment II, both post-training PS-deprived and pre-test PS-deprived groups showed memory deficits per se. However, only the pre-test PS-deprived animals presented anxiolytic-like behavior and increased locomotor activity. In Experiment III, pre-training PS-deprived rats showed learning and memory deficits, anxiolytic-like behavior and increased locomotor activity. A 24 h-sleep recovery period after the PSD abolished the learning and memory deficits but not anxiety and locomotor alterations. Finally, sleep rebound did not modify acquisition (Experiment III) and retrieval (Experiment IV). This study strengthened the critical role of paradoxical sleep (but not sleep rebound) in all the phases of learning and memory formation. In addition, it suggests that PSD effects on acquisition and consolidation do not seem to be related to other behavioral alterations induced by this procedure. (C) 2008 Elsevier Inc. All rights reserved.