Herne oxygenase-1 and carbon monoxide regulate intestinal homeostasis and mucosal immune responses to the enteric microbiota
Herne oxygenase-1 and carbon monoxide regulate intestinal homeostasis and mucosal immune responses to the enteric microbiota
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DOI：
10.4161/gmic.27290
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发表时间：
2014-01-01
期刊：
影响因子：
12.2
通讯作者：
Plevy, Scott E.
中科院分区：
文献类型：
--
作者：
Onyiah, Joseph C.;Sheikh, Shehzad Z.;Plevy, Scott E.
血红素加氧酶-1 (HO-1) 及其酶副产物一氧化碳 (CO) 已成为急性和慢性炎症的重要调节因子。其抗炎作用的机制目前尚不完全清楚。在本附录中，我们总结了目前对 HO-1/CO 通路在调节肠道炎症中的作用的理解，重点关注先天免疫功能。我们特别强调我们最近的发现，即 HO-1 和 CO 通过促进细菌清除来改善肠道炎症。我们和许多其他人的工作支持进一步研究人类炎症性肠病（IBD）中的这种全局稳态途径。
Heme oxygenase-1 (HO-1) and its enzymatic by-product carbon monoxide (CO) have emerged as important regulators of acute and chronic inflammation. Mechanisms underlying their anti-inflammatory effects are only partially understood. In this addendum, we summarize current understanding of the role of the HO-1/CO pathway in regulation of intestinal inflammation with a focus on innate immune function. In particular, we highlight our recent findings that HO-1 and CO ameliorate intestinal inflammation through promotion of bacterial clearance. Our work and that of many others support further investigation of this global homeostatic pathway in the human inflammatory bowel diseases (IBDs).