A role of androgen receptor protein in cell growth of an androgen-independent prostate cancer cell line
A role of androgen receptor protein in cell growth of an androgen-independent prostate cancer cell line
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DOI：
10.1271/bbb.69.2236
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发表时间：
2005-11-01
影响因子：
1.6
通讯作者：
Kato, S
中科院分区：
文献类型：
--
作者：
Furutani, T;Takeyama, KI;Kato, S
前列腺癌是由于雄激素而发生的，最初对雄激素剥夺治疗有反应，通常在短期内获得雄激素剥夺治疗抗性。我们研究了雄激素受体（AR）蛋白在雄激素非依赖性前列腺癌细胞系中的作用，使用AR配体和AR siRNA。虽然雄激素非依赖性细胞系几乎没有响应AR配体，它们的生长减弱的AR蛋白的siRNA消融。
Prostate cancer, which develops due to androgen and is initially responsive to androgen deprivation therapy, often comes to acquire androgen deprivation therapy resistance in short order. We investigated the role of androgen receptor (AR) protein in an androgen-independent prostate cancer cell line using AR ligands and AR siRNA. Although the androgen-independent cell line scarcely responded to AR ligands, their growth was attenuated by ablation of AR protein by siRNA.