Intracranial presentation of systemic Hodgkin's disease
Intracranial presentation of systemic Hodgkin's disease
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DOI：
10.1080/10428190410001673409
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发表时间：
2004-08-01
影响因子：
2.6
通讯作者：
Couban, S
中科院分区：
文献类型：
--
作者：
Hirmiz, K;Foyle, A;Couban, S
何杰金氏病累及颅内是罕见的。我们报告一个何杰金氏病的病人，在就诊时有颅内疾病。我们也回顾了有关颅内何杰金氏病的文献。使用关键词“霍奇金病”和“中枢神经系统（CNS）疾病”，我们检索了Pubmed和Cancerlit数据库。参考文献进行了系统的审查，并提取有关以下变量的数据：年龄，性别，体征和症状的介绍，霍奇金病的组织学，脑脊液分析，阶段和治疗。文献中仅发现36例颅内霍奇金病。颅内何杰金氏病在介绍更是罕见，只有8例报告。大多数霍奇金病累及颅内的病例发生在复发时。颅内何杰金氏病最常见的表现是颅神经麻痹，脑实质是最常见的颅内受累部位。混合细胞组织学是这些患者中最常见的霍奇金病亚型，颅内表现后的中位生存期为46个月。治疗方法多种多样，但包括全脑放射治疗，联合或不联合化疗。我们的文献回顾显示，适当的治疗预后并不差。
Intracranial involvement by Hodgkin's disease is rare. We report a patient with Hodgkin's disease who had intracranial disease at presentation. We also review the literature pertaining to intracranial Hodgkin's disease. Using the key words "Hodgkin's disease" and "central nervous system (CNS) disease", we searched the Pubmed and Cancerlit databases. References were systematically reviewed and data regarding the following variables was extracted: age, gender, signs and symptoms at presentation, histology of Hodgkin's disease, cerebrospinal fluid analysis, stage and treatment. Only 36 cases of intracranial Hodgkin's disease were identified in the literature. Intracranial Hodgkin's disease at presentation is even more uncommon with only 8 reported cases. Most cases of intracranial involvement by Hodgkin's disease occur at the time of relapse. The most common presenting feature of intracranial Hodgkin's disease is a cranial nerve palsy with brain parenchyma being the most common intracranial site of involvement. Mixed cellularity histology is the most frequent subtype of Hodgkin's disease among these patients and the median survival following intracranial presentation is 46 months. Treatment has varied extensively but includes whole brain radiation with or without combination chemotherapy. Our literature review suggests that the prognosis is not dismal with appropriate treatment.