The intestinal microbiome and skeletal fitness: Connecting bugs and bones
The intestinal microbiome and skeletal fitness: Connecting bugs and bones
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DOI：
10.1016/j.clim.2015.03.019
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发表时间：
2015-08-01
影响因子：
8.6
通讯作者：
Aliprantis, Antonios O.
中科院分区：
文献类型：
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作者：
Charles, Julia F.;Ermann, Joerg;Aliprantis, Antonios O.
最近的进展极大地增加了我们对器官系统如何相互作用的理解。对于免疫学和骨生物学来说尤其如此，其中术语“骨免疫学”被创造出来以捕捉这种关系。微生物组对免疫系统的重要性也成为健康和疾病的驱动因素。因此，提出这样一个问题是有意义的：肠道微生物组如何影响骨骼生物学，生态失调是否会促进骨骼疾病？令人惊讶的是，很少有研究分析这种联系。对这个问题的更广泛的解释揭示了微生物组可能影响骨细胞的许多机制。这些包括微生物组对免疫细胞的影响，包括骨髓祖细胞和Th17细胞，以及类固醇激素，脂肪酸，血清素和维生素D。随着微生物组和骨骼系统在免疫系统内外的机械相互作用的揭示，可能会出现优化骨骼健康的新策略。(C)2015 Elsevier Inc. All rights reserved.
Recent advances have dramatically increased our understanding of how organ systems interact. This has been especially true for immunology and bone biology, where the term "osteoimmunology" was coined to capture this relationship. The importance of the microbiome to the immune system has also emerged as a driver of health and disease. It makes sense therefore to ask the question: how does the intestinal microbiome influence bone biology and does dysbiosis promote bone disease? Surprisingly, few studies have analyzed this connection. A broader interpretation of this question reveals many mechanisms whereby the microbiome may affect bone cells. These include effects of the microbiome on immune cells, including myeloid progenitors and Th17 cells, as well as steroid hormones, fatty acids, serotonin and vitamin D. As mechanistic interactions of the microbiome and skeletal system are revealed within and without the immune system, novel strategies to optimize skeletal fitness may emerge. (C) 2015 Elsevier Inc. All rights reserved.