Regeneration techniques for bone-to-tendon and muscle-to-tendon interfaces reconstruction
Regeneration techniques for bone-to-tendon and muscle-to-tendon interfaces reconstruction
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DOI：
10.1093/bmb/ldv056
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发表时间：
2016-03-01
影响因子：
6.7
通讯作者：
Reverchon, Ernesto
中科院分区：
文献类型：
--
作者：
Baldino, Lucia;Cardea, Stefano;Reverchon, Ernesto
骨-肌腱和肌肉-肌腱连接的复杂结构使得它们在组织工程中的复制非常困难。相对较少的研究从组织工程的角度研究了这些区域的特征。数据来源：PubMed、Thomson Reuters、Scopus和谷歌Scholar数据库使用关键词“肌腱”、“肌腱连接”、“骨腱连接”、“组织工程”和“支架”的不同组合进行搜索。一致的领域：现有的研究可以根据目标是建立一个完整的复合组织单元还是辅助界面的重建来划分，例如改善自体移植物与周围骨骼或肌肉的整合。目前最常用的技术是基于静电纺丝和自重组结构过程，这些技术应用于骨-肌腱连接（BTJ）和肌肉-肌腱连接（MTJ）的再生。纳米纤维的使用模拟细胞外基质（ECM）的分层结构，最终通过包封生物活性成分实现功能化，允许细胞附着和分化。争议领域：没有翻译研究。生长点：有必要设计合适的技术，允许合适的组织工程BTJ和MTJ。及时开展研究的领域：需要适当计划的研究，将组织工程从科学挑战转化为临床应用技术。
Introduction: The complex structure of the bone-tendon and muscle-tendon junctions makes their reproduction for tissue engineering applications very difficult. Relatively few studies have investigated the characteristics of these regions from a tissue engineering view point.Sources of data: PubMed, Thomson Reuters, Scopus and Google Scholar databases were searched using various combinations of the keywords 'Tendon', 'Myotendinous junction', 'Osteotendinous junction', 'Tissue engineering' and 'Scaffold'.Areas of agreement: The available studies can be divided according to whether the objective is to build an entire composite tissue unit or to assist the recreation of interfaces, such as improving integration of autografts with the surrounding bone or with the muscle. The most used techniques are based on the electrospinning and the self-reorganized constructs process, which were applied to both bone-to-tendon junction (BTJ) and muscle-to-tendon junction (MTJ) regeneration. The use of nanofibers that mimic the hierarchical structure of the extracellular matrix (ECM), eventually functionalized by encapsulation of bioactive components, allowed cell attachment and differentiation.Areas of controversy: There have been no translational investigations.Growing points: There is a need to devise suitable techniques that allow suitable tissue engineering of BTJ and MTJ.Areas timely for developing research: Appropriately planned studies are needed to translate tissue engineering from a scientific challenge to a clinically applicable technique.