A Comparison of Attitudes Toward Opioid Agonist Treatment among Short-Term Buprenorphine Patients
A Comparison of Attitudes Toward Opioid Agonist Treatment among Short-Term Buprenorphine Patients
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DOI：
10.3109/00952990.2011.643983
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发表时间：
2012-05-01
影响因子：
2.7
通讯作者：
Schwartz, Robert P.
中科院分区：
文献类型：
--
作者：
Kelly, Sharon M.;Brown, Barry S.;Schwartz, Robert P.
背景资料：获得关于美国阿片类药物依赖者对丁丙诺啡和美沙酮态度的数据可能有助于时尚方法，以增加治疗进入和改善患者结局。目的：这项次要分析研究比较了接受短期丁丙诺啡治疗（BT）的阿片类药物依赖成人与接受美沙酮维持治疗或未接受治疗的阿片类药物依赖成人对美沙酮和丁丙诺啡的态度。研究方法：417名参与者包括132名进入短期BT的人，191名进入美沙酮维持治疗的人，以及94名未寻求治疗的人。参与者被管理的美沙酮量表和它的同伴对丁丙诺啡量表的态度。使用卡方检验和单因素方差分析比较三组的人口统计学特征。一个重复测量的多变量方差分析与计划的对比被用来比较各组之间的平均态度得分。结果如下：进入BT的参与者对丁丙诺啡的积极态度显著高于美沙酮（p < .001），对BT的积极态度高于美沙酮治疗（MT）参与者和治疗外（OT）参与者（p < .001）。此外，BT参与者对美沙酮的积极态度低于MT参与者（p <0.001）。结论：参与者对特定药物有明显的偏好。向OT个体提供药物选择可能会提高他们进入治疗的可能性。治疗方案应尽可能为新患者提供药物选择，未来的比较有效性研究应将患者的偏好纳入临床试验。科学意义：这些数据有助于我们理解为什么人们寻求或不寻求阿片类药物成瘾的有效药物治疗。
Background: Obtaining data on attitudes toward buprenorphine and methadone of opioid-dependent individuals in the United States may help fashion approaches to increase treatment entry and improve patient outcomes. Objectives: This secondary analysis study compared attitudes toward methadone and buprenorphine of opioid-dependent adults entering short-term buprenorphine treatment (BT) with opioid-dependent adults who are either entering methadone maintenance treatment or not entering treatment. Methods: The 417 participants included 132 individuals entering short-term BT, 191 individuals entering methadone maintenance, and 94 individuals not seeking treatment. Participants were administered an Attitudes toward Methadone scale and its companion Attitudes toward Buprenorphine scale. Demographic characteristics for the three groups were compared using chi(2) tests of independence and one-way analysis of variance. A repeated-measures multivariate analysis of variance with planned contrasts was used to compare mean attitude scores among the groups. Results: Participants entering BT had significantly more positive attitudes toward buprenorphine than toward methadone (p < .001) and more positive attitudes toward BT than methadone-treatment (MT) participants and out-of-treatment (OT) participants (p < .001). In addition, BT participants had less positive attitudes toward methadone than participants entering MT (p < .001). Conclusions: Participants had a clear preference for a particular medication. Offering a choice of medications to OT individuals might enhance their likelihood of entering treatment. Treatment programs should offer a choice of medications when possible to new patients, and future comparative effectiveness research should incorporate patient preferences into clinical trials. Scientific Significance: These data contribute to our understanding of why people seek or do not seek effective pharmacotherapy for opioid addiction.