A comparison of the diagnostic accuracy and prognostic value of the first and second anti-cyclic citrullinated peptides (CCP1 and CCP2) autoantibody tests for rheumatoid arthritis
A comparison of the diagnostic accuracy and prognostic value of the first and second anti-cyclic citrullinated peptides (CCP1 and CCP2) autoantibody tests for rheumatoid arthritis
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DOI：
10.1136/ard.2004.035089
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发表时间：
2005-10-01
影响因子：
27.4
通讯作者：
Huizinga, TWJ
中科院分区：
文献类型：
--
作者：
van Gaalen, FA;Visser, H;Huizinga, TWJ
目的：比较抗环瓜氨酸肽（CCP 1）和抗CCP 2自身抗体检测在临床setting.Methods的诊断性能和预后价值：抗CCP 1和抗CCP 2抗体检测进行相同的血清样本从467例早期关节炎莱顿关节炎队列。在1年的随访中，计算两种试验区分类风湿性关节炎（RA）和非RA的敏感性、特异性、阳性预测值和阴性预测值。使用受试者工作特征曲线以图形方式显示结果。放射性关节损伤的进展进行了评估，超过4年的RA患者，并用于评估的CCP tests.Results：在一个类似的特异性的CCP 2测试有更高的灵敏度比CCP 1测试的misticstics值。这两项试验都确定了一个关节损伤进展率增加的RA患者亚组。抗CCP 2测试确定更多的患者与关节损伤进展的增加率比抗CCP 1测试，并在多元回归分析CCP 2是更好的预测关节damage.Conclusions：CCP 2测试有更好的诊断和预后能力比CCP 1测试。
Objectives: To compare the diagnostic performance and prognostic value of the anti-cyclic citrullinated peptide (CCP1) and anti-CCP2 autoantibody tests in a clinical setting.Methods: Anti-CCP1 and anti-CCP2 antibody tests were performed on the same serum samples obtained from 467 patients with early arthritis from the Leiden Arthritis Cohort. The sensitivity, specificity, positive predictive value, and negative predictive value for discriminating between rheumatoid arthritis ( RA) and non-RA at 1 year's follow up were calculated for both tests. Results were graphically presented using receiver operating characteristic curves. Progression of radiological joint damage was assessed over 4 years in patients with RA and used to assess the prognostics values of the CCP tests.Results: At a similar specificity the CCP2 test had a higher sensitivity than the CCP1 test. Both tests identified a subgroup of patients with RA with an increased rate of joint damage progression. The anti-CCP2 test identified more patients with an increased rate of joint damage progression than the anti-CCP1 test, and in multiple regression analysis CCP2 was the better predictor of joint damage.Conclusions: The CCP2 test had better diagnostic and prognostic ability than the CCP1 test.