Validation of the Seventh Edition of the American Joint Committee on Cancer TNM Staging System for Gastric Cancer
Validation of the Seventh Edition of the American Joint Committee on Cancer TNM Staging System for Gastric Cancer
复制标题
DOI：
10.1002/cncr.25778
复制
发表时间：
2011-06-01
期刊：
影响因子：
6.2
通讯作者：
Park, Cho Hyun
中科院分区：
文献类型：
--
作者：
Jung, Hun;Lee, Han Hong;Park, Cho Hyun
背景：第七版美国癌症联合委员会（AJCC）胃癌TNM分类于2010年发布，并进行了重大修订。本研究的目的是评估基于亚洲人群的第七版TNM胃癌分类的有效性。方法：纳入1989年至2008年同一研究所共2916例行逆转录酶手术切除的胃癌患者，并根据第七版TNM分类进行分析验证。结果：当使用TNM第七版分类进行调整时，与TNM第六版分类相比，771例患者（26.4%）出现分期上升，178例患者（6.1%）出现分期下降。与第6版pT分级相比，第7版pT分级的相对危险度（RR）随强度的增加而增加。与第6版pN分类相比，第7版pN分类的RR增加且强度不规则。在生存分析中，每个疾病阶段都有显著差异，但IA期和IB期之间只有边际差异（P= 0.049）。结合第7版pT分型和第6版pN分型的混合TNM分型中，pT分型和pN分型的RR分布更为理想，各分期的5年生存率也有显著差异(P
BACKGROUND: The seventh edition of the American Joint Committee on Cancer (AJCC) TNM classification for gastric cancer was published in 2010 and included major revisions. The aim of the current study was to evaluate the validity of the seventh edition TNM classification for gastric cancer based on an Asian population. METHODS: A total of 2916 gastric cancer patients who underwent RO surgical resection from 1989 through 2008 in a single institute were included, and were analyzed according to the seventh edition of the TNM classification for validation. RESULTS: When adjusted using the seventh edition of the TNM classification, upstaging was observed in 771 patients (26.4%) and downstaging was observed in 178 patients (6.1%) compared with the sixth edition of the TNM classification. The relative risk (RR) of seventh edition pT classification was found to be increased with regular intensity compared with the sixth edition pT classification. The RR of seventh edition pN classification was found to be increased with irregular intensity compared with the sixth edition pN classification. In survival analysis, there were significant differences noted for each stage of disease, but only a marginal difference was demonstrated between stage IA and stage IB (P=.049). In the hybrid TNM classification, which combines the seventh edition pT classification and the sixth edition pN classification, both pT and pN classifications demonstrated a more ideal distribution of the RR, and 5-year survival rates also showed a significant difference for each stage (P