Expression of c-Fos protein in the trigeminal nuclear complex resulting from quantified force application to the rat molar.
Expression of c-Fos protein in the trigeminal nuclear complex resulting from quantified force application to the rat molar.
复制标题
c-Fos 蛋白在三叉神经核复合体中的表达，是由于对大鼠磨牙施加量化的力而产生的。
DOI：
10.1046/j.1365-2842.2003.01158.x
复制
发表时间：
2003
影响因子：
2.9
通讯作者：
K. Tanne
中科院分区：
文献类型：
--
作者：
M. Watanabe;E. Tanaka;S. Suemune;T. Satoda;N. Maeda;T. Uchida;K. Tanne
本研究观察了大鼠三叉神经感觉核复合体中c-Fos样免疫反应神经元(Fos-神经元)的表达和分布。分别对牙齿施加25、50和100g的力，作用时间为2 h，对上磨牙施加100g的定量力，作用时间分别为[短时间(1~2 min)]、2、4、8和12 h，FOS神经元分布于双侧尾侧亚核浅层和同侧口亚核背内侧部。尾侧亚核(Sp5C)内Fos神经元的数量随力的大小而增加。在Sp5C中，Fos神经元的数量在给药后2或4小时达到最高水平。在Sp50dm，Fos神经元的数量在8h达到最高水平，这些数据表明Sp5C内伤害性神经元数量的变化反映了牙齿受力大小的编码变化，正畸力引起的疼痛反应的性质可能与Sp50dm中c-Fos蛋白的延迟表达有关。
This study was conducted to investigate the expression and distribution of c-Fos-like immunoreactive neurones (Fos-neurones), in the rat trigeminal sensory nuclear complex, produced by mechanical forces with various magnitudes and durations applied to the left upper first molar. The magnitudes of forces applied to the tooth were 25, 50 and 100 g and the duration was 2 h. A quantified force of 100 g was also applied to the upper molar for varying durations [short-time (1-2 min)], 2, 4, 8 and 12 h. Fos-neurones distributed in the bilateral superficial laminae of the subnucleus caudalis, and the ipsilateral dorsomedial part of subnucleus oralis (Sp5Odm). The number of Fos-neurones increased in the subnucleus caudalis (Sp5C) according to the force magnitude. In the Sp5C, the number of Fos-neurones exhibited maximum level, 2 or 4 h after the application. In the Sp5Odm, however, the number of Fos-neurones reached the maximum level at 8 h. These data suggest that the change in the number of nociceptive neurones in Sp5C reflect changes in encoding the magnitude of force to tooth, and that the nature of pain response to orthodontic forces might have some relation to the delayed expression of c-Fos protein in the Sp5Odm.
Fujiyoshi, Y.：“实验性牙齿运动后大鼠髓质背角和三叉神经口亚核之间 c-Fos 免疫反应神经元的时间分布差异”《神经科学快报》。
DOI：
--
发表时间：
--
期刊：
影响因子：
--
作者：
通讯作者：
--