Dental follicle stem cells and tissue engineering.
Dental follicle stem cells and tissue engineering.
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DOI：
10.2334/josnusd.52.541
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发表时间：
2010-12-01
影响因子：
1.9
通讯作者：
Morsczeck, Christian
中科院分区：
文献类型：
--
作者：
Honda, Masaki J;Imaizumi, Mari;Morsczeck, Christian
成体干细胞具有多能性，可以通过实验诱导分化成多种细胞系。因此，这种细胞是实现组织再生的关键部分。研究最多的干细胞是造血干细胞和间充质干细胞。近年来，间充质干细胞在牙髓、牙周韧带、牙毛囊等牙组织中得到了广泛的应用。牙毛囊是一种松散的结缔组织，包裹着正在发育的牙齿。因此，牙滤泡干细胞可能是间充质干细胞的细胞来源。实际上，牙毛囊存在于阻生牙齿中，在牙科实践中通常被作为医疗废物提取和处理。牙滤泡干细胞可以在特定的组织培养条件下分离和生长，最近对这些干细胞的描述增加了它们在组织工程应用中的潜力，包括牙周和骨再生。本文综述了目前有关牙滤泡干细胞及其应用的研究进展。
Adult stem cells are multipotent and can be induced experimentally to differentiate into various cell lineages. Such cells are therefore a key part of achieving the promise of tissue regeneration. The most studied stem cells are those of the hematopoietic and mesenchymal lineages. Recently, mesenchymal stem cells were demonstrated in dental tissues, including dental pulp, periodontal ligament, and dental follicle. The dental follicle is a loose connective tissue that surrounds the developing tooth. Dental follicle stem cells could therefore be a cell source for mesenchymal stem cells. Indeed, dental follicle is present in impacted teeth, which are commonly extracted and disposed of as medical waste in dental practice. Dental follicle stem cells can be isolated and grown under defined tissue culture conditions, and recent characterization of these stem cells has increased their potential for use in tissue engineering applications, including periodontal and bone regeneration. This review describes current knowledge and recent developments in dental follicle stem cells and their application.