ENERGY-PRESERVING MUSCLE TISSUE MODEL: FORMULATION AND COMPATIBLE DISCRETIZATIONS
ENERGY-PRESERVING MUSCLE TISSUE MODEL: FORMULATION AND COMPATIBLE DISCRETIZATIONS
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DOI：
10.1615/intjmultcompeng.2011002360
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发表时间：
2012-01-01
影响因子：
1.4
通讯作者：
Sorine, M.
中科院分区：
文献类型：
--
作者：
Chapelle, D.;Le Tallec, P.;Sorine, M.
在本文中，我们提出了一个肌肉组织模型有效的横纹肌，在一般情况下，和心肌，特别是基于多尺度的生理描述。该模型扩展和完善了早期提出的公式，允许人们解释所有主要的能量交换和平衡，从与氧气供应相结合的化学活性到实际机械功的产生，即组织的生物学功能。因此，我们进行了彻底的分析，在各种尺度上的能量机制，并继续提出一个完整的离散化策略，在时间和空间尊重相同的平衡定律。这将是至关重要的，在未来的工作，充分模拟许多重要的生理正常和病理现象与这些能源的考虑。
In this paper, we propose a muscle tissue model valid for striated muscles, in general, and for the myocardium, in particular based on a multiscale physiological description. This model extends and refines an earlier-proposed formulation by allowing one to account for all major energy exchanges and balances, from the chemical activity coupled with oxygen supply to the production of actual mechanical work, namely, the biological function of the tissue. We thus perform a thorough analysis of the energy mechanisms prevailing at the various scales and proceed to propose a complete discretization strategy in time and space respecting the same balance laws. This will be crucial in future works to adequately model the many important physiological normal and pathological phenomena associated with these energy considerations.