Correlation of Aging and Segmental Choroidal Thickness Measurement using Swept Source Optical Coherence Tomography in Healthy Eyes.
Correlation of Aging and Segmental Choroidal Thickness Measurement using Swept Source Optical Coherence Tomography in Healthy Eyes.
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DOI：
10.1371/journal.pone.0144156
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Yuzawa M
中科院分区：
文献类型：
--
作者：
Wakatsuki Y;Shinojima A;Kawamura A;Yuzawa M
为了评估和比较与衰老相关的脉络膜厚度变化，我们使用波长为1，050 nm的扫频光源光学相干断层扫描（SS-OCT）确定变化是否是由于健康眼中的脉络膜毛细血管层加Sattler（CS）层和/或大血管层变薄所致。我们研究了115名健康志愿者的115只正常眼，所有眼的屈光不正均小于-6屈光度。所有115只眼睛都接受了中心凹、CS层和脉络膜大血管层的脉络膜厚度分析。在115只眼睛中的68只眼睛中，使用SS-OCT和糖尿病视网膜病变早期治疗网格扫描在5个部位（中央凹、上级、下级、鼻侧和颞侧部位）确定脉络膜厚度。五个部位的脉络膜总厚度与受试者年龄相关（P<0.0001）。鼻侧脉络膜最薄，其次是颞侧、下侧、上级，最后是中心凹下部位。鼻侧脉络膜总厚度显著小于其他4个部位（p<0.05）。CS层随年龄增长而变薄（P<0.0001）。脉络膜大血管层的厚度也随着年龄的增长而降低（p = 0.02）。计算中心凹下脉络膜厚度：443.89-2.98×年龄（μm）（P<0.0001）。中心凹下脉络膜厚度每年减少2.98 μm。脉络膜总厚度随年龄增长而减小。CS和脉络膜的大血管层在中心凹下表现出显着下降，虽然只有前者与年龄密切相关。
To assess and compare choroidal thickness changes related to aging, we determined whether changes are due to thinning of the choriocapillaris plus Sattler's (CS) layer and/or the large vessel layer in healthy eyes using swept-source optical coherence tomography (SS-OCT) at a wavelength of 1,050-nm. We studied 115 normal eyes of 115 healthy volunteers, all with refractive errors of less than -6 diopters. All 115 eyes underwent analysis of choroidal thickness at the fovea, the CS layer and the large choroidal vessel layer. In 68 of the 115 eyes, choroidal thickness was determined at five sites (the fovea, and superior, inferior, nasal, and temporal sites) using SS-OCT with an Early Treatment of Diabetic Retinopathy grid scan. Total choroidal thicknesses at each of the five sites were related to subject age (P<0.0001). The choroid was thinnest at the nasal site, followed by the temporal, inferior, superior and finally the subfoveal site itself. The total choroidal thickness at the nasal site was significantly less than those at the other four sites (p<0.05). The CS layer showed thinning which correlated with age (P<0.0001). The thickness of the choroidal large vessel layer also decreased with age (p = 0.02). Subfoveal choroidal thickness was calculated as follows: 443.89–2.98×age (μm) (P<0.0001). Subfoveal choroidal thickness decreases by 2.98 μm each year. Total choroidal thickness diminishes with age. The CS and large vessel layers of the choroid at the subfovea showed significant decreases, though only the former correlated strongly with age.