The multifaceted roles of PARP1 in DNA repair and chromatin remodelling.
The multifaceted roles of PARP1 in DNA repair and chromatin remodelling.
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DOI：
10.1038/nrm.2017.53
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发表时间：
2017-10
期刊：
影响因子：
--
通讯作者：
Nussenzweig A
中科院分区：
文献类型：
--
作者：
Ray Chaudhuri A;Nussenzweig A
细胞暴露于诱导DNA损伤的各种内源性和外源性损伤，如果不修复，则会损害基因组完整性并导致包括癌症在内的各种疾病的发展。最近的证据表明，聚（ADP-核糖）聚合酶1（PARP 1）在各种DNA修复途径和基因组稳定性的维护。因此，PARP 1的抑制在临床上被用于治疗各种癌症，包括DNA修复缺陷型卵巢癌、乳腺癌和前列腺癌。了解PARP 1在维持基因组完整性中的作用不仅对设计新型化疗药物很重要，而且对深入了解癌细胞的化疗耐药性机制也至关重要。在这篇综述中，我们讨论了PARP 1在介导DNA代谢的各个方面的作用，如单链断裂修复，核苷酸切除修复，双链断裂修复和复制叉的稳定，并在调节染色质结构。
Cells are exposed to various endogenous and exogenous insults that induce DNA damage, which, if unrepaired, impairs genome integrity and leads to the development of various diseases, including cancer. Recent evidence has implicated poly(ADP-ribose) polymerase 1 (PARP1) in various DNA repair pathways and in the maintenance of genomic stability. The inhibition of PARP1 is therefore being exploited clinically for the treatment of various cancers, which include DNA repair-deficient ovarian, breast and prostate cancers. Understanding the role of PARP1 in maintaining genome integrity is not only important for the design of novel chemotherapeutic agents, but is also crucial for gaining insights into the mechanisms of chemoresistance in cancer cells. In this Review, we discuss the roles of PARP1 in mediating various aspects of DNA metabolism, such as single-strand break repair, nucleotide excision repair, double-strand break repair and the stabilization of replication forks, and in modulating chromatin structure.
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影响因子：
--
作者：
Aguilar-Quesada R;Muñoz-Gámez JA;Martín-Oliva D;Peralta A;Valenzuela MT;Matínez-Romero R;Quiles-Pérez R;Menissier-de Murcia J;de Murcia G;Ruiz de Almodóvar M;Oliver FJ
通讯作者：
Oliver FJ
影响因子：
16.8
作者：
Berti, Matteo;Chaudhuri, Arnab Ray;Thangavel, Saravanabhavan;Gomathinayagam, Shivasankari;Kenig, Sasa;Vujanovic, Marko;Odreman, Federico;Glatter, Timo;Graziano, Simona;Mendoza-Maldonado, Ramiro;Marino, Francesca;Lucic, Bojana;Biasin, Valentina;Gstaiger, Matthias;Aebersold, Ruedi;Sidorova, Julia M.;Monnat, Raymond J., Jr.;Lopes, Massimo;Vindigni, Alessandro
通讯作者：
Vindigni, Alessandro
影响因子：
16.6
作者：
Ahuja AK;Jodkowska K;Teloni F;Bizard AH;Zellweger R;Herrador R;Ortega S;Hickson ID;Altmeyer M;Mendez J;Lopes M
通讯作者：
Lopes M
影响因子：
64.8
作者：
Ray Chaudhuri A;Callen E;Ding X;Gogola E;Duarte AA;Lee JE;Wong N;Lafarga V;Calvo JA;Panzarino NJ;John S;Day A;Crespo AV;Shen B;Starnes LM;de Ruiter JR;Daniel JA;Konstantinopoulos PA;Cortez D;Cantor SB;Fernandez-Capetillo O;Ge K;Jonkers J;Rottenberg S;Sharan SK;Nussenzweig A
通讯作者：
Nussenzweig A
影响因子：
5.3
作者：
CALDECOTT, KW;MCKEOWN, CK;THOMPSON, LH
通讯作者：
THOMPSON, LH