Competing Endogenous RNA Regulations in Neurodegenerative Disorders: Current Challenges and Emerging Insights.
Competing Endogenous RNA Regulations in Neurodegenerative Disorders: Current Challenges and Emerging Insights.
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DOI：
10.3389/fnmol.2018.00370
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发表时间：
2018
影响因子：
4.8
通讯作者：
Wan J
中科院分区：
文献类型：
--
作者：
Cai Y;Wan J
在过去的十年里，见证了令人兴奋的突破，这些突破促进了蓬勃发展的现代RNA世界的丰富性和复杂性，其中一个特别的突破-竞争内源RNA(Cerna)假说-被描述为解码用于调节RNA串扰和调节生物功能的RNA语言的“罗塞塔石头”。拟议的影响深远的机制将不同的RNA物种联合起来，并为以前未被识别的RNA-RNA相互作用和RNA调控网络提供了新的见解，这些网络可能以有组织的、分级的方式决定基因的表达。最近发现的Cerna调控环和网络强调了Cerna调控在广泛的发育阶段和病理背景下的力量，例如在肿瘤发生和神经退行性疾病中。尽管Cerna假说极大地提高了我们对RNA生物学的理解，但在该假说提出后不久，争议主要与已报道的Cerna调控在生理条件下的作用存在微小差异有关，这导致Cerna调控成为一个被广泛研究和快速增长的研究领域。在这里，我们集中在支持Cerna在神经退行性疾病中调控的证据，并解决与Cerna调控机制相关的三个关键点：microRNA(MiRNA)和Cerna在交叉调控中的层次结构；Cerna-miRNA相互作用中失稳和稳定结合之间的平衡；Cerna调控机制在健康和疾病中的真实参与程度，以及当前CERNA研究中的实验缺陷。
The past decade has witnessed exciting breakthroughs that have contributed to the richness and complexity of a burgeoning modern RNA world, and one particular breakthrough—the competing endogenous RNA (ceRNA) hypothesis—has been described as the “Rosetta Stone” for decoding the RNA language used in regulating RNA crosstalk and modulating biological functions. The proposed far-reaching mechanism unites diverse RNA species and provides new insights into previously unrecognized RNA–RNA interactions and RNA regulatory networks that perhaps determine gene expression in an organized, hierarchical manner. The recently uncovered ceRNA regulatory loops and networks have emphasized the power of ceRNA regulation in a wide range of developmental stages and pathological contexts, such as in tumorigenesis and neurodegenerative disorders. Although the ceRNA hypothesis drastically enhanced our understanding of RNA biology, shortly after the hypothesis was proposed, disputes arose in relation mainly to minor discrepancies in the reported effects of ceRNA regulation under physiological conditions, and this resulted in ceRNA regulation becoming an extensively studied and fast-growing research field. Here, we focus on the evidence supporting ceRNA regulation in neurodegenerative disorders and address three critical points related to the ceRNA regulatory mechanism: the microRNA (miRNA) and ceRNA hierarchies in cross-regulations; the balance between destabilization and stable binding in ceRNA–miRNA interactions; and the true extent to which ceRNA regulatory mechanisms are involved in both health and disease, and the experimental shortcomings in current ceRNA studies.
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影响因子：
16
作者：
Bosson, Andrew D.;Zamudio, Jesse R.;Sharp, Phillip A.
通讯作者：
Sharp, Phillip A.
影响因子：
16.8
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DOI：
10.1126/science.1215704
发表时间：
2012-04-13
期刊：
Science (New York, N.Y.)
影响因子：
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作者：
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通讯作者：
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DOI：
10.1073/pnas.052704499
发表时间：
2002-03-05
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
64.5
作者：
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通讯作者：
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