AUTOANTIBODY TO AN IMMUNOREGULATORY INDUCER POPULATION IN PATIENTS WITH JUVENILE RHEUMATOID-ARTHRITIS
AUTOANTIBODY TO AN IMMUNOREGULATORY INDUCER POPULATION IN PATIENTS WITH JUVENILE RHEUMATOID-ARTHRITIS
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DOI：
10.1172/jci110092
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发表时间：
1981-01-01
影响因子：
15.9
通讯作者：
SCHLOSSMAN, SF
中科院分区：
文献类型：
--
作者：
MORIMOTO, C;REINHERZ, EL;SCHLOSSMAN, SF
The human inducer (T4+) and reciprocal cytotoxic/suppressor (T5t+/T8+) [T cell] subsets were defined by monoclonal antibodies. The relationship of naturally occurring anti-T cell autoantibodies found in patients with active juvenile rheumatoid arthritis (JRA) to these subsets was examined. Normal T cells were treated with anti-T4 or anti-T8 to eliminate the corresponding subset of cells and then analyzed for JRA sera reactivity. JRA sera were reactive with only 15% of an enriched cytotoxic/suppressor population, whereas they reacted with 37% of an enriched inducer population. In reciprocal studies, JRA+ T cells were eliminated with JRA sera and complement [c] and the residual T cells (JRA-) reacted with monoclonal antibodies and indirect immunofluorescence on a fluorescence-activated cell sorter. The JRA sera and C treatment of unfractionated T cells markedly diminished the T4+ subset, whereas there was a concomitant increase in T cells reactive with anti-T5 and anti-T8. A similar diminution in T4+ T cells was found in the circulating peripheral T cell compartment of active JRA patients who possessed the JRA antibody. Functional studies demonstrated that removal of the JRA+ population of T cells diminished phytohemagglutinin and soluble antigen proliferative responses, both of which were previously shown to be functions of T4+ T cells. In the absence of JRA+ T cells, pokeweed mitogen-stimulated Ig production was markedly enhanced, despite the concomitant increase in T5+/T8+ cytotoxic/suppressor cells. Apparently the JRA serum may define a Qal-like antigen found predominantly on the human inducer population which could activate suppressor and/or other feedback regulatory cells.
