Integration of an anti-tumor drug into nanocrystalline assemblies for sustained drug release.
Integration of an anti-tumor drug into nanocrystalline assemblies for sustained drug release.
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DOI：
10.1039/c4sc03392b
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发表时间：
2015-03-01
期刊：
影响因子：
8.4
通讯作者：
Hou Z
中科院分区：
文献类型：
--
作者：
Yang X;Wu S;Li Y;Huang Y;Lin J;Chang D;Ye S;Xie L;Jiang Y;Hou Z
一种生物启发的方法被用来整合一种抗肿瘤药物到纳米晶组装持续药物释放。精细的介观结构，承载着复杂的形式和多层次，导致生物矿物的重要功能。在此，生物启发的方法被开发用于制造抗肿瘤药物10-羟基喜树碱（HCPT）的彗星状组装体。HCPT和赋形剂- PEG-b-PLGA -在乳化剂内的抗溶剂共沉淀导致彗星束的立即成核，随后是二次成核以产生彗星头，其是几乎平行排列的纳米纤维的组装体。连续生产使药物-赋形剂混合颗粒具有高载药量和持续药物释放特性。这种简单而有效的生物启发的方法导致了一个有前途的持续局部药物输送系统，并可以扩展到其他功能有机材料的制造轴承介观结构单元。
A bio-inspired approach was used to integrate an anti-tumor drug into nanocrystalline assemblies for sustained drug release. Delicate mesoscopic architectures, bearing complex forms with multiple hierarchy levels, lead to significant functions in biogenic minerals. Herein, a bio-inspired approach was developed to fabricate comet-shaped assemblies of an anti-tumor drug – 10-hydroxycamptothecin (HCPT). The anti-solvent co-precipitation of HCPT and the excipient – PEG-b-PLGA – within the emulsifier leads to the immediate nucleation of comet bundles, followed by a secondary nucleation to generate the comet head, which is an assembly of nanofibers aligned almost in parallel. The continuous manufacturing furnishes drug–excipient hybrid particles with high drug-loading and a sustained drug release profile. This simple and efficient bio-inspired approach led to a promising sustained local drug delivery system, and could be extended to the fabrication of other functional organic materials bearing mesoscopic structural units.