Duration of allergic susceptibility in maternal transmission of asthma risk
Duration of allergic susceptibility in maternal transmission of asthma risk
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DOI：
10.1111/j.1600-0897.2007.00496.x
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发表时间：
2007-08-01
影响因子：
3.6
通讯作者：
Kobzik, Lester
中科院分区：
文献类型：
--
作者：
Fedulov, Alexey V.;Leme, Adriana S.;Kobzik, Lester
问题哮喘有它的起源在早期的生活。方法用卵清蛋白（OVA）致敏哮喘小鼠和正常小鼠的1、3、6和10周龄的后代，2周后用雾化的OVA激发，并检测气道高反应性（AHR）和过敏性气道炎症（AI）。但不正常，母亲在OVA致敏后第1周表现出AHR和AI。同样，在3周或6周致敏时观察到对OVA的敏感性增加，尽管幅度减小。后代致敏在10和挑战，在12 wk显示一些AI，但没有AHR.Conclusion在后代哮喘母亲的过敏易感性增加持续通过青年期，虽然逐渐下降，这表明一个长期的，但可逆的发展中的免疫系统的倾斜。
Problem Asthma has its origins in early-life. Maternal, not paternal asthma is an important risk factor, but the mechanisms and the duration of the maternal effect are unknown.Method of Study Offspring of asthmatic and normal mice were sensitized with ovalbumin (OVA) at 1, 3, 6 and 10 weeks of age, challenged with aerosolized OVA 2 weeks later and tested for airway hyperresponsiveness (AHR) and allergic airway inflammation (AI).Results Offspring of asthmatic, but not normal, mothers showed AHR and AI after OVA sensitization at week 1. Similarly increased susceptibility to OVA was observed when sensitized at 3 or 6 weeks, although the magnitude diminished. Offspring sensitized at 10 and challenged at 12 weeks showed some AI but no AHR.Conclusion In offspring from asthmatic mothers increased allergic susceptibility persisted through the young adulthood, albeit with gradual decline, which suggests a long-lived but reversible skewing of the developing immune system.