Instability and spatiotemporal dynamics of alternans in paced cardiac tissue
Instability and spatiotemporal dynamics of alternans in paced cardiac tissue
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DOI：
10.1103/physrevlett.88.208101
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发表时间：
2002-05-20
影响因子：
8.6
通讯作者：
Karma, A
中科院分区：
文献类型：
--
作者：
Echebarria, B;Karma, A
我们推导出一个方程，管理的小幅度交替在起搏心脏组织的时空动态。我们发现，一个图案形成的线性不稳定性导致自发形成的固定或行波的节点划分成区域的组织与动作电位持续时间的振荡相反的相位。这种不稳定性是重要的，因为如果组织尺寸超过图案波长的一小部分，则其动态地创建用于形成传导阻滞和诱导纤颤的异质电基底。我们推导出这个波长的解析表达式作为色散和细胞间电耦合相关的三个基本长度尺度的函数。
We derive an equation that governs the spatiotemporal dynamics of small amplitude alternans in paced cardiac tissue. We show that a pattern-forming linear instability leads to the spontaneous formation of stationary or traveling waves whose nodes divide the tissue into regions with opposite phase of oscillation of action potential duration. This instability is important because it creates dynamically a heterogeneous electrical substrate for the formation of conduction blocks and the induction of fibrillation if the tissue size exceeds a fraction of the pattern wavelength. We derive an analytical expression for this wavelength as a function of three basic length scales related to dispersion and intercellular electrical coupling.