Depressive Symptoms and Cognitive Decline in Community-Dwelling Older Adults
Depressive Symptoms and Cognitive Decline in Community-Dwelling Older Adults
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DOI：
10.1111/j.1532-5415.2010.02807.x
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发表时间：
2010-05-01
影响因子：
6.3
通讯作者：
Allardyce, Judith
中科院分区：
文献类型：
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作者：
Kohler, Sebastian;van Boxtel, Martin P. J.;Allardyce, Judith
目的研究抑郁症状和认知功能之间的时间关联，并评估载脂蛋白E（APOE）β 4等位基因修饰对这种关系的影响。在3年（N=479）和6年（N=412）后进行重新评估。（症状自评量表）和神经认知功能（记忆，视觉语言学习测试;注意力，Stroop色词测试;处理速度，字母数字替换测试;一般认知，简易精神状态检查）。使用线性混合模型评估纵向关联。采用逻辑回归分析研究了认知功能障碍、非痴呆（CIND）的风险。根据年龄、性别、教育程度和基线认知进行调整后，基线时抑郁症状最低（参考组）、第二、第三和最高四分位数的记忆Z评分的变化率分别为0.00、-0.11、-0.20和-0.37（P
OBJECTIVESTo examine the temporal association between depressive symptoms and cognitive functioning and estimate the effect measure modification of the apolipoprotein E (APOE) epsilon 4 allele on this relationship.DESIGNProspective cohort study.SETTINGGeneral community.PARTICIPANTSPopulation-based sample of 598 cognitively intact older adults aged 60 and older, with re-assessments after 3 (N=479) and 6 years (N=412).MEASUREMENTSDepressive symptoms (Symptom Checklist) and neurocognitive functioning (memory, Visual Verbal Learning Test; attention, Stroop Color-Word Test; processing speed, Letter Digit Substitution Test; general cognition, Mini-Mental State Examination). Longitudinal associations were assessed using linear mixed models. The risk for cognitive impairment, no dementia (CIND) was examined using logistic regression.RESULTSAdjusting for age, sex, education, and baseline cognition, the rate of change in memory z-scores was 0.00, -0.11, -0.20, and -0.37 for those in the lowest (reference group), second, third, and highest depressive symptom quartiles at baseline, respectively (P