Association of DASH diet with cardiovascular risk factors in youth with diabetes mellitus: the SEARCH for Diabetes in Youth study.
Association of DASH diet with cardiovascular risk factors in youth with diabetes mellitus: the SEARCH for Diabetes in Youth study.
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DOI：
10.1161/circulationaha.110.955922
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发表时间：
2011-04-05
期刊：
影响因子：
37.8
通讯作者：
Marcovina S
中科院分区：
文献类型：
--
作者：
Liese AD;Bortsov A;Günther AL;Dabelea D;Reynolds K;Standiford DA;Liu L;Williams DE;Mayer-Davis EJ;D'Agostino RB Jr;Bell R;Marcovina S
我们已经证明，坚持饮食方法来阻止高血压（DASH）饮食与1型和2型糖尿病青年的血压有关。我们探讨了DASH饮食对其他心血管疾病危险因素的影响。在2001年至2005年期间，确定了2130名10至22岁的医生诊断为糖尿病的青年的总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、甘油三酯、低密度脂蛋白颗粒密度、载脂蛋白B、体重指数、腰围和脂肪细胞因子的数据。通过食物频率问卷评估饮食摄入，将其分为DASH食物组，并分配依从性评分。在多变量校正模型中，1型糖尿病青年患者中，DASH饮食依从性较高与低密度脂蛋白/高密度脂蛋白比值和A1 c呈显著负相关。与调整混杂因素后的最低三分位数相比，最高依从性三分位数的年轻人的低密度脂蛋白/高密度脂蛋白比率估计低0.07，A1 c水平低0.2。未观察到与甘油三酯、低密度脂蛋白颗粒密度、脂肪细胞因子、载脂蛋白B、体重指数Z评分或腰围的显著相关性。在青年2型糖尿病患者中，观察到低密度脂蛋白颗粒密度和体重指数Z评分的相关性。DASH饮食模式可能有助于预防和管理糖尿病青年的心血管疾病风险。
We have shown that adherence to the Dietary Approaches to Stop Hypertension (DASH) diet is related to blood pressure in youth with type 1 and type 2 diabetes mellitus. We explored the impact of the DASH diet on other cardiovascular disease risk factors. Between 2001 and 2005, data on total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, low-density lipoprotein particle density, apolipoprotein B, body mass index, waist circumference, and adipocytokines were ascertained in 2130 youth aged 10 to 22 years with physician-diagnosed diabetes mellitus. Dietary intake was assessed by food frequency questionnaire, categorized into the DASH food groups, and assigned an adherence score. Among youth with type 1 diabetes mellitus, higher adherence to the DASH diet was significantly and inversely associated with low-density lipoprotein/high-density lipoprotein ratio and A1c in multivariable-adjusted models. Youth in the highest adherence tertile had an estimated 0.07 lower low-density lipoprotein/high-density lipoprotein ratio and 0.2 lower A1c levels than those in the lowest tertile adjusted for confounders. No significant associations were observed with triglycerides, low-density lipoprotein particle density, adipocytokines, apolipoprotein B, body mass index Z score, or waist circumference. Among youth with type 2 diabetes mellitus, associations were observed with low-density lipoprotein particle density and body mass index Z score. The DASH dietary pattern may be beneficial in the prevention and management of cardiovascular disease risk in youth with diabetes mellitus.