Betting on improved cancer immunotherapy by doubling down on CD134 and CD137 co-stimulation.
Betting on improved cancer immunotherapy by doubling down on CD134 and CD137 co-stimulation.
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DOI：
10.4161/onci.22837
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发表时间：
2013-01-01
期刊：
影响因子：
7.2
通讯作者：
Vella AT
中科院分区：
文献类型：
--
作者：
Adler AJ;Vella AT
T 细胞识别大量抗原的能力使它们能够摧毁肿瘤细胞，同时造成最小的附带损害。然而，肿瘤抗原通常是自身抗原的一种形式，因此肿瘤免疫可能会被为防止自身免疫而进化的耐受机制所抑制。由于提供不充分共刺激的稳态抗原呈递细胞可以诱导耐受，因此外源施用共刺激激动剂可以有利于肿瘤特异性T细胞的扩增和杀肿瘤功能。共刺激肿瘤坏死因子受体 (TNFR) 家族成员 CD134 和 CD137 的激动剂在小鼠体内发挥抗肿瘤活性，并且作为单一疗法在临床试验中表现出令人鼓舞的结果。本综述重点关注 CD134 和 CD137 激动剂的双重给药如何协同促进 T 细胞启动并阐述多管齐下的抗肿瘤免疫反应，以及如何将这种双重共刺激转化为有效的抗癌疗法。
The ability of T cells to recognize a vast array of antigens enables them to destroy tumor cells while inflicting minimal collateral damage. Nevertheless, tumor antigens often are a form of self-antigen, and thus tumor immunity can be dampened by tolerance mechanisms that evolved to prevent autoimmunity. Since tolerance can be induced by steady-state antigen-presenting cells that provide insufficient co-stimulation, the exogenous administration of co-stimulatory agonists can favor the expansion and tumoricidal functions of tumor-specific T cells. Agonists of the co-stimulatory tumor necrosis factor receptor (TNFR) family members CD134 and CD137 exert antitumor activity in mice, and as monotherapies have exhibited encouraging results in clinical trials. This review focuses on how the dual administration of CD134 and CD137 agonists synergistically boosts T-cell priming and elaborates a multi-pronged antitumor immune response, as well as how such dual co-stimulation might be translated into effective anticancer therapies.
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影响因子：
82.9
作者：
Chen, CD;Welsbie, DS;Sawyers, CL
通讯作者：
Sawyers, CL
DOI：
10.1084/jem.179.3.1005
发表时间：
1994-03-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Bakker AB;Schreurs MW;de Boer AJ;Kawakami Y;Rosenberg SA;Adema GJ;Figdor CG
通讯作者：
Figdor CG
DOI：
10.1084/jem.20050915
发表时间：
2005-12-19
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Casares N;Pequignot MO;Tesniere A;Ghiringhelli F;Roux S;Chaput N;Schmitt E;Hamai A;Hervas-Stubbs S;Obeid M;Coutant F;Métivier D;Pichard E;Aucouturier P;Pierron G;Garrido C;Zitvogel L;Kroemer G
通讯作者：
Kroemer G
影响因子：
11.2
作者：
Cohen, AD;Diab, A;Houghton, AN
通讯作者：
Houghton, AN
影响因子：
6.4
作者：
Cuadros, C;Dominguez, AL;Lustgarten, J
通讯作者：
Lustgarten, J