DISTINCT BIOLOGICAL AND SEROLOGICAL PROPERTIES OF HUMAN IMMUNODEFICIENCY VIRUSES FROM THE BRAIN
DISTINCT BIOLOGICAL AND SEROLOGICAL PROPERTIES OF HUMAN IMMUNODEFICIENCY VIRUSES FROM THE BRAIN
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DOI：
10.1002/ana.410230716
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发表时间：
1988-01-01
影响因子：
11.2
通讯作者：
LEVY, JA
中科院分区：
文献类型：
--
作者：
CHENGMAYER, C;LEVY, JA
来自脑的人类免疫缺陷病毒可通过其感染已建立的人类细胞系的能力和其对血清中和的敏感性与外周血分离物区分。从同一人获得的脑和淋巴结分离物显示出相似的宿主范围嗜性和对血清中和的敏感性;然而，脑分离物更有效地感染巨噬细胞。这些数据表明，脑分离物可能代表了人类免疫缺陷病毒的一种独特亚型。
Human immunodeficiency viruses from the brain can be distinguished from peripheral blood isolates by their ability to infect established human cell lines and their sensitivity to serum neutralization. Isolates from the brain and lymph nodes obtained from the same person displayed similar host range tropism and susceptibility to serum neutralization; however, the brain isolate infected macrophages more efficiently. These data suggest that brain isolates may represent a distinct subtype of the human immunodeficiency virus.