Factors that Influence Intent to Share Genetic Information Related to Cancer Risk with Family Members
Factors that Influence Intent to Share Genetic Information Related to Cancer Risk with Family Members
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DOI：
10.1080/10810730.2021.1968078
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发表时间：
2021-09-01
影响因子：
4.4
通讯作者：
Sharp, Richard R.
中科院分区：
文献类型：
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作者：
Stuttgen Finn, Kelsey;Pacyna, Joel E.;Sharp, Richard R.
我们描述了影响患者决定与家人分享阳性癌症基因检测结果的因素。我们关注的患者被诊断患有几种不同的癌症类型，但没有提示遗传风险的家族史。参与者从马约诊所招募，最近被诊断患有癌症。进行了80+基因面板。在收到基因检测结果之前，患者完成了一项49项关于他们与亲属分享结果意图的调查。在2,984名选择进行基因检测的人中，有1,721人（57.7%）完成了调查。大多数患者计划与配偶或伴侣（97.0%），至少一个成年子女（92.2%），至少一个兄弟姐妹（86.2%）和至少一个父母（70.3%）分享癌症相关的遗传结果。家庭支持分数和家庭沟通分数可以预测分享癌症相关基因检测结果的意图。我们的数据突出了家庭沟通能力和支持的差异，这对于临床医生在支持希望与家庭成员分享癌症相关基因检测结果的患者时非常重要。我们的数据指出了几种潜在的干预策略，这些策略可能会增加癌症相关基因检测结果与风险家庭成员共享的可能性。
We describe factors influencing patient decisions to share positive cancer genetic test results with family members. We focused on patients who were diagnosed with several different cancer types but did not have a family history that was suggestive of an inherited risk. Participants were recruited from Mayo Clinic and had been recently diagnosed with cancer. An 80+ gene panel was performed. Before receiving genetic test results, patients completed a 49-item survey on their intent to share their results with relatives. 1,721 (57.7%) of 2,984 individuals who elected to pursue genetic testing completed the survey. Most patients planned to share cancer-related genetic results with a spouse or partner (97.0%), at least one adult child (92.2%), at least one sibling (86.2%), and with at least one parent (70.3%). Familial support scores and familial communication scores were predictive of intent to share cancer-related genetic test results. Our data highlight differences in family communication capacity and support that are important for clinicians to consider when supporting patients who wish to share cancer-related genetic test results with family members. Our data point to several potential interventional strategies that might increase the likelihood of cancer-related genetic test results being shared with family members at risk.