The interplay between macrophages and angiogenesis in development, tissue injury and regeneration
The interplay between macrophages and angiogenesis in development, tissue injury and regeneration
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DOI：
10.1387/ijdb.103227sn
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发表时间：
2011-01-01
影响因子：
0.7
通讯作者：
De Palma, Michele
中科院分区：
文献类型：
--
作者：
Nucera, Silvia;Biziato, Daniela;De Palma, Michele
在器官发育和重塑过程中，巨噬细胞不仅通过分泌促血管生成生长因子和基质重塑蛋白酶，而且通过与萌芽的脉管系统物理相互作用以辅助复杂血管网络的形成来支持血管生成。最近的数据进一步表明，胚胎和肿瘤相关的巨噬细胞表达类似的遗传程序，可能表明在器官发生和肿瘤发生的趋同功能。在这篇文章中，我们回顾了巨噬细胞在发育，组织损伤和再生中的作用，通过关注这些细胞的亚群，如TIE 2表达的巨噬细胞，在胎儿和出生后的生活中调节血管生成和淋巴管生成的机制。
During organ development and remodeling, macrophages support angiogenesis, not only by secreting proangiogenic growth factors and matrix-remodeling proteases, but also by physically interacting with the sprouting vasculature to assist the formation of complex vascular networks. Recent data further indicate that embryonic and tumor-associated macrophages express similar genetic programs, possibly suggesting convergent functions in organogenesis and tumorigenesis. In this article, we review the role of macrophages in development, tissue injury and regeneration, by focusing on the mechanisms used by subsets of these cells, such as the TIE2-expressing macrophages, to regulate angiogenesis and lymphangiogenesis in both fetal and post-natal life.