Outbreak of human parainfluenza virus 3 infections in a hematopoietic stem cell transplant population
Outbreak of human parainfluenza virus 3 infections in a hematopoietic stem cell transplant population
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DOI：
10.1086/322041
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发表时间：
2001-11-01
影响因子：
6.4
通讯作者：
Bennett, JE
中科院分区：
文献类型：
--
作者：
Cortez, KJ;Erdman, DD;Bennett, JE
对2000年春异基因造血干细胞移植受者11周内发生的12例人副流感病毒3型感染的临床表现和流行病学特征进行了描述。以上呼吸道症状为主。3名患者发生肺炎，1名患者死亡。HPIV3分离株的暴露史和分子分析表明，在此次暴发期间发生了社区获得性感染和医院传播感染。门诊内的传播链似乎发生在4名门诊患者中，并已扩展到2名住院患者。分子流行病学有助于识别此次暴发的传播途径。
Clinical manifestations and epidemiological features are described for a cluster of 12 cases of human parainfluenza virus 3 (HPIV3) infection that occurred among 64 allogeneic hematopoietic stem cell transplant (SCT) recipients in an 11-week period during spring 2000. Upper respiratory symptoms predominated. Pneumonia occurred in 3 patients and was a contributing factor in the death of 1 patient. Exposure histories and molecular analysis of HPIV3 isolates suggested that both community acquired and nosocomially transmitted infections occurred during this outbreak. A chain of transmission within the outpatient clinic appeared to have occurred in 4 outpatients and to have extended to 2 hospitalized patients. Molecular epidemiology was useful in discerning routes of transmission in this outbreak.