Peptide conjugation via CuAAC 'click' chemistry.
Peptide conjugation via CuAAC 'click' chemistry.
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通过CUAAC“点击”化学反应肽结合。
DOI：
10.3390/molecules181113148
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发表时间：
2013-10-24
期刊：
影响因子：
--
通讯作者：
Toth I
中科院分区：
文献类型：
--
作者：
Ahmad Fuaad AA;Azmi F;Skwarczynski M;Toth I
The copper (I)-catalyzed alkyne azide 1,3-dipolar cycloaddition (CuAAC) or ‘click’ reaction, is a highly versatile reaction that can be performed under a variety of reaction conditions including various solvents, a wide pH and temperature range, and using different copper sources, with or without additional ligands or reducing agents. This reaction is highly selective and can be performed in the presence of other functional moieties. The flexibility and selectivity has resulted in growing interest in the application of CuAAC in various fields. In this review, we briefly describe the importance of the structural folding of peptides and proteins and how the 1,4-disubstituted triazole product of the CuAAC reaction is a suitable isoster for an amide bond. However the major focus of the review is the application of this reaction to produce peptide conjugates for tagging and targeting purpose, linkers for multifunctional biomacromolecules, and reporter ions for peptide and protein analysis.
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肽和蛋白质产生的化学方法。
DOI：
10.3390/molecules18044373
发表时间：
2013-04-12
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Chandrudu S;Simerska P;Toth I
通讯作者：
Toth I
影响因子：
6.2
作者：
Dehn, Sabrina;Castelletto, Valeria;Perrier, Sebastien
通讯作者：
Perrier, Sebastien
影响因子：
4.3
作者：
de Araujo, Aline Dantas;Palomo, Jose M.;Waldmann, Herbert
通讯作者：
Waldmann, Herbert
影响因子：
15
作者：
Angelo, NG;Arora, PS
通讯作者：
Arora, PS
影响因子：
15
作者：
DUVIGNEAUD, V;RESSLER, C;KATSOYANNIS, PG
通讯作者：
KATSOYANNIS, PG