Axonal stimulation affects the linear summation of single-point perception in three Argus II users.
Axonal stimulation affects the linear summation of single-point perception in three Argus II users.
复制标题
轴突刺激影响三个 Argus II 用户的单点感知的线性总和。
DOI：
10.1101/2023.07.21.23292908
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Beyeler,Michael
中科院分区：
文献类型：
--
作者：
Hou,Yuchen;Nanduri,Devyani;Granley,Jacob;Weiland,JamesD;Beyeler,Michael
视网膜植入物使用电刺激来引起感知的闪光（“光幻视”）。单电极光幻视的形状已被证明是系统地改变与刺激参数和刺激电极的视网膜位置，由于偶然激活通过神经纤维束。然而，这方面的知识还没有扩展到配对电极stimulation.ApproachWe回顾性分析了3548光幻视图纸由三个盲人参与者植入了阿格斯II视网膜假体。光幻视的形状（其特征在于面积，周长，长轴和短轴长度）和数量的感知光幻视的平均试验，并与相应的单电极参数。此外，光幻视的数量与刺激幅度和神经解剖学参数相关：电极-视网膜和电极-中央凹距离以及电极-电极距离（“轴突之间”）和沿着轴突束（“沿轴突”）。主要结果简单回归分析表明，每一对电极形状描述符都可以通过两个相应的单电极形状描述符之和来预测（p<0.05）。001）的情况下。多元回归分析显示，成对电极光幻视形状主要由刺激幅度和电极-中心凹距离预测（p<. 05）。有趣的是，诱发的光幻视的数量倾向于随着轴突间距离的增加而增加（p<0.05）。显著性双电极刺激诱发的光幻视的形状与其对应的单电极光幻视的形状具有很好的预测性，表明两点感知可以表示为单点感知的线性和。轴突间距离对感知光幻视数量的影响提供了支持视网膜前刺激轴突图模型的进一步证据。这些发现有助于越来越多的文献光幻视知觉和未来的视网膜假体的设计具有重要意义。
ObjectiveRetinal implants use electrical stimulation to elicit perceived flashes of light ('phosphenes'). Single-electrode phosphene shape has been shown to vary systematically with stimulus parameters and the retinal location of the stimulating electrode, due to incidental activation of passing nerve fiber bundles. However, this knowledge has yet to be extended to paired-electrode stimulation.ApproachWe retrospectively analyzed 3548 phosphene drawings made by three blind participants implanted with an Argus II Retinal Prosthesis. Phosphene shape (characterized by area, perimeter, major and minor axis length) and number of perceived phosphenes were averaged across trials and correlated with the corresponding single-electrode parameters. In addition, the number of phosphenes was correlated with stimulus amplitude and neuroanatomical parameters: electrode-retina and electrode-fovea distance as well as the electrode-electrode distance to ('between-axon') and along axon bundles ('along-axon'). Statistical analyses were conducted using linear regression and partial correlation analysis.Main resultsSimple regression revealed that each paired-electrode shape descriptor could be predicted by the sum of the two corresponding single-electrode shape descriptors (p<. 001). Multiple regression revealed that paired-electrode phosphene shape was primarily predicted by stimulus amplitude and electrode-fovea distance (p<. 05). Interestingly, the number of elicited phosphenes tended to increase with between-axon distance (p<. 05), but not with along-axon distance, in two out of three participants.SignificanceThe shape of phosphenes elicited by paired-electrode stimulation was well predicted by the shape of their corresponding single-electrode phosphenes, suggesting that two-point perception can be expressed as the linear summation of single-point perception. The impact of the between-axon distance on the perceived number of phosphenes provides further evidence in support of the axon map model for epiretinal stimulation. These findings contribute to the growing literature on phosphene perception and have important implications for the design of future retinal prostheses.