Shedding genomic ballast: Extensive parallel loss of ancestral gene families in animals
Shedding genomic ballast: Extensive parallel loss of ancestral gene families in animals
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DOI：
10.1007/s00239-004-0115-7
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发表时间：
2004-12-01
影响因子：
3.9
通讯作者：
Friedman, R
中科院分区：
文献类型：
--
作者：
Hughes, AL;Friedman, R
祖先基因家族的丢失在动物基因组特化中起着重要作用。对完全测序的动物基因组中基因家族丢失模式的检查表明，如果基因丢失是随机发生的，相同的基因家族在不同谱系中独立丢失的程度远高于预期。这一结果意味着某些祖先基因家族以及它们所编码的生物学功能在动物门的辐射中比其他基因家族更容易被消耗掉。
Loss of ancestral gene families has played an important role in genomic specialization in animals. An examination of the pattern of gene family loss in completely sequenced animal genomes revealed that the same gene families have been lost independently in different lineages to a far greater extent than expected if gene loss occurred at random. This result implies that certain ancestral gene families-and thus the biological functions they encode-have been more expendable than others over the radiation of the animal phyla.