Automated analysis of behavior: A computer-controlled system for drug screening and the investigation of learning
Automated analysis of behavior: A computer-controlled system for drug screening and the investigation of learning
复制标题
DOI：
10.1002/neu.20290
复制
发表时间：
2006-08-01
期刊：
影响因子：
--
通讯作者：
Levin, Michael
中科院分区：
文献类型：
--
作者：
Hicks, Caitlin;Sorocco, Debra;Levin, Michael
计算机系统能够自动分析动物行为，这将极大地促进理解认知的努力。在无脊椎动物学习领域的一些争议是由于人工实验固有的困难造成的。在研究涡虫扁虫和青蛙幼虫的神经功能时，为了克服这些问题，我们设计并开发了一个廉价、灵活的系统原型，可以自动控制和分析行为和学习。该系统适用于各种小动物，如扁虫和斑马鱼，可以自动分析先天行为，以及在大量条件反射范式下的学习和记忆。我们在这里展示了一个基本原型的原理图，它克服了实验者的影响和操作员的乏味，使大量的动物能够通过透明的在线访问原始数据进行分析。该技术的放大版代表了一种有效的方法来筛选药理学和遗传文库，以寻找与基础和生物医学相关的新型神经活性试剂。(c) 2006 Wiley期刊公司
Efforts to understand cognition will be greatly facilitated by computerized systems that enable the automated analysis of animal behavior. A number of controversies in the invertebrate learning field have resulted from difficulties inherent in manual experiments. Driven by the necessity to overcome these problems during investigation of neural function in planarian flatworms and frog larvae, we designed and developed a prototype for an inexpensive, flexible system that enables automated control and analysis of behavior and learning. Applicable to a variety of small animals such as flatworms and zebralish, this system allows automated analysis of innate behavior, as well as of learning and memory in a plethora of conditioning paradigms. We present here the schematics of a basic prototype, which overcomes experimenter effects and operator tedium, enabling a large number of animals to be analyzed with transparent on-line access to primary data. A scaled-up version of this technology represents an efficient methodology to screen pharmacological and genetic libraries for novel neuroactive reagents of basic and biomedical relevance. (c) 2006 Wiley Periodicals, Inc.