Effect of short-duration spaceflight on thigh and leg muscle volume
Effect of short-duration spaceflight on thigh and leg muscle volume
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DOI：
10.1097/00005768-200010000-00013
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发表时间：
2000-10-01
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影响因子：
--
通讯作者：
Fukunaga, T
中科院分区：
文献类型：
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作者：
Akima, H;Kawakami, Y;Fukunaga, T
目的：人类骨骼肌可能会因太空飞行而萎缩，但很少有研究探讨这个问题。因此，人们对微重力对人体骨骼肌的影响知之甚少，也不可能评估地面空间飞行模型的有效性。这项研究检验了这样一种假设，即航天飞行引起的肌肉萎缩的程度是飞行时间的函数，并且大于卧床休息引起的肌肉萎缩。方法：三名宇航员在太空中飞行9，15和16天。膝伸肌（股四头肌）、膝屈肌（腘绳肌、缝匠肌和股薄肌）和跖屈肌（小腿三头肌）肌肉群的体积在航天飞行前后和恢复期间使用磁共振成像进行测量。通过将横截面积乘以切片厚度来确定每个图像中每个肌肉组的体积。随后将这些值相加以计算肌肉体积。结果：膝伸肌的体积变化。膝屈肌和跖屈肌群分别为-15.4 ~-5.5、-14.1 ~-5.6和-8.8 ~-15.9%。按飞行持续时间标准化的肌肉体积减少范围为0.62至1.04%.d（-1）。这些相对变化似乎大于我们先前报道的卧床休息的变化（Akima等人，J. Gravitat. 4：15-22，1997）。结论：这些结果表明，由于至少2周的空间飞行的萎缩不同的个人和肌肉群，萎缩的程度似乎是大于20天的卧床休息。
Purpose: Human skeletal muscle probably atrophies as a result of spaceflight, but few studies have examined this issue. Thus, little is known about the influence of microgravity upon human skeletal muscle, nor is it possible to assess the validity of ground based models of spaceflight. This study tested the hypothesis that the magnitude of spaceflight induced muscle atrophy would be a function of flight duration and greater than that of bed rest. Methods: Three astronauts flew 9, 15, and 16 d in space. Volume of the knee extensor (quadriceps femoris), knee flexor (hamstrings, sartorius, and gracilis), and plantar flexor (triceps surae) muscle groups was measured using magnetic resonance imaging before and after spaceflight and during recovery. The Volume of each muscle group in each image was determined by multiplying cross-sectional area by slice thickness. These values were subsequently summed to calculate muscle volume. Results: Volume changes in the knee extensor. knee flexor, and plantar flexor muscle groups ranged from -15.4 to -5.5, -14.1 to -5.6, and -8.8 to -15.9%, respectively. Muscle volume decreases normalized by flight duration ranged from 0.62 to 1.04%.d(-1). These relative changes appeared to be greater than those that we have reported previously for bed rest (Akima et al., J. Gravitat. Physiol. 4:15-22, 1997). Conclusions: These results suggest that atrophy as a result of at least 2 wk of spaceflight varied among individuals and muscle groups and that the degree of atrophy appeared to be greater than that induced by 20 d of bed rest.