ALTERATION OF PLATELET SEROTONERGIC MECHANISMS AND MONOAMINE-OXIDASE ACTIVITY IN PREMENSTRUAL-SYNDROME
ALTERATION OF PLATELET SEROTONERGIC MECHANISMS AND MONOAMINE-OXIDASE ACTIVITY IN PREMENSTRUAL-SYNDROME
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DOI：
10.1016/0006-3223(88)90277-6
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发表时间：
1988-06-01
影响因子：
10.6
通讯作者：
FRANKS, DD
中科院分区：
文献类型：
--
作者：
ASHBY, CR;CARR, LA;FRANKS, DD
Platelet uptake and content of 5-hydroxytryptamine (5-HT), platelet monoamine oxidase (MAO) activity, and plasma free and total tryptophan levels were determined in patients diagnosed with premenstrual syndrome (PMS) and in control subjects. The Vmax of 5-HT uptake and 5-HT content in platelets of PMS patients were significantly decreased during the premenstrual phase (cycle days -9 to -1) compared to control subjects. Platelet MAO activity was significantly lower postmenstrually (cycle days 5-9) in PMS patients compared to the premenstrual phase. There were no differences in plasma free and total tryptophan levels between PMS patients and control subjects during either interval. As platelets are believed to be a peripheral model for central serotonergic neurons, the results suggest that PMS symptomatology may be related to alterations in serotonergic neuronal mechanisms.
