Occurrence of Pharmaceuticals Used in Human and Veterinary Medicine in Aquatic Environments in Japan
Occurrence of Pharmaceuticals Used in Human and Veterinary Medicine in Aquatic Environments in Japan
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日本水生环境中人用和兽用药物的出现情况
DOI：
10.2965/jswe.27.685
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
S. Masunaga
中科院分区：
文献类型：
--
作者：
A. Seino;Sanae Furusho;S. Masunaga
近年来，由于其可能增加微生物的抗生素耐药性及其对水生生物的生态影响，水生环境中的药物引起了欧洲和北美的广泛关注。但是，日本报告的信息很少。在这项研究中，我们报告了日本水生环境中人类和兽药的水平。一个液相色谱仪与串联质谱仪被用来检测这些化合物。结果表明，在ng·l-1水平上可检出某些药物。位于城市地区的河流中人用药物的浓度高于郊区，而主要用于兽药的药物在郊区的浓度较高。在污水处理厂的废水中也检测出了人体药物。在农业废水中检测到的部分兽用抗生素浓度高达μg·l-1，在某些特定区域可能产生生态效应。
In recent years, pharmaceuticals in the aquatic environment have attracted much attention in Europe and North America due to their potential to increase antibiotic resistance in microorganisms and their ecological effects on aquatic organisms. Little information, however, has been reported from Japan. In this study, we report on the levels of human and veterinary pharmaceuticals in aquatic environments in Japan. A liquid chromatograph coupled with a tandem mass spectrometer was used to detect these compounds. The results showed that certain pharmaceuticals were detected at ng·l-1 level. The concentrations of human pharmaceuticals in rivers located in urban areas were higher than those in suburban areas, while pharmaceuticals mainly used for veterinary medicine were found of higher concentration in suburban areas. Human pharmaceuticals were also detected the sewage treatment plant effluent. In agricultural wastewater, some antibiotics for veterinary use were detected at high concentrations of up to μg·l-1 level, which indicated possible ecological effects in some limited areas.