Ocular manifestations and treatment of syphilis.
Ocular manifestations and treatment of syphilis.
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DOI：
10.1080/08820530500232092
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发表时间：
2005-07-01
影响因子：
1.7
通讯作者：
Young, Lucy H
中科院分区：
文献类型：
--
作者：
Kiss, Szilard;Damico, Francisco Max;Young, Lucy H
梅毒是由梅毒螺旋体引起的性传播的慢性全身性感染。如果不治疗，疾病会经过四个阶段，有可能对身体的任何主要器官造成严重的发病率。梅毒常见的眼部表现可发生在疾病的任何阶段，包括间质性角膜炎、前、中、后色素层炎、脉络膜视网膜炎、视网膜炎、视网膜血管炎以及脑神经和视神经病变。诊断主要集中在高度临床怀疑，包括密螺旋体特异性和非密螺旋体血清学试验。所有新诊断的梅毒患者都应进行人类免疫缺陷病毒合并感染检测，因为这两种疾病的风险因素相似。此外，所有眼梅毒患者都应进行神经梅毒检测。所有阶段梅毒的首选治疗仍然是注射青霉素G。通过正确的诊断和及时的抗生素治疗，大多数梅毒病例可以治愈。
Syphilis is a sexually transmitted, chronic, systemic infection caused by the spirochete Treponema pallidum. If left untreated, the disease progresses through four stages, with the potential to cause significant morbidity to any major organ of the body. Frequent syphilitic ocular manifestations, which can occur at any stage of the disease, include interstitial keratitis, anterior, intermediate, and posterior uveitis, chorioretinitis, retinitis, retinal vasculitis and cranial nerve and optic neuropathies. Diagnosis is centered around a high level of clinical suspicion and includes treponemal specific and non-treponemal serologic tests. All patients with newly diagnosed syphilis should be tested for co-infection with human immunodeficiency virus, as the risk factors are similar for both diseases. Additionally, all patients with ocular syphilis should be tested for neurosyphilis. The preferred treatment for all stages of syphilis remains parenteral penicillin G. With proper diagnosis and prompt antibiotic treatment, the majority of cases of syphilis can result in a cure.