Decrease in resting metabolic rate during rapid weight loss is reversed by low dose thyroid hormone treatment.
Decrease in resting metabolic rate during rapid weight loss is reversed by low dose thyroid hormone treatment.
复制标题
快速减肥过程中静息代谢率的降低可以通过低剂量甲状腺激素治疗逆转。
DOI：
10.1016/0026-0495(86)90142-3
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Campbell,RG
中科院分区：
文献类型：
--
作者：
Welle,SL;Campbell,RG
为了确定快速减肥过程中血清 T3 浓度降低是否会导致静息代谢率 (RMR) 降低，我们向接受极低能量饮食的肥胖受试者施用 T3（30 μg/d）和 T4（100 μg/d），以逆转血清甲状腺激素浓度的降低。在减重的前两周，在甲状腺激素替代之前，五名肥胖受试者的平均 RMR 下降至基线水平的 86%，而平均血清 T3 浓度下降至基线水平的 72%。甲状腺激素替代治疗一周，同时继续低能量饮食，将平均 RMR 增加至基线水平的 94%，同时将平均血清 T3 和 T4 浓度增加至基线水平的约 130%。甲状腺治疗第二周没有导致 RMR 进一步变化。这些数据表明，血清 T3 浓度降低有助于快速减肥过程中 RMR 的降低。然而，尽管将血清甲状腺激素浓度提高到略高于体重维持水平，但采用的甲状腺激素替代方案并没有完全恢复能量极低的肥胖受试者的正常RMR。
In order to determine if reduced serum T3concentrations contribute to the decrease in resting metabolic rate (RMR) during rapid weight loss, we administered T3(30 μg/d) and T4(100 μg/d) to obese subjects receiving a very low energy diet to reverse a decrease in serum thyroid hormone concentrations. During the first two weeks of weight loss, before thyroid hormone replacement, the mean RMR of five obese subjects declined to 86% of the baseline level as the mean serum T3concentration decreased to 72% of the baseline level. Thyroid hormone replacement for one week, while the low energy diet continued, increased the mean RMR to 94% of the baseline level while increasing mean serum T3and T4concentrations to approximately 130% of the baseline level. A second week of thyroid treatment caused no further change in RMR. These data suggest that reduced serum T3concentrations contribute to the decrease in RMR during rapid weight loss. However, the regimen of thyroid hormone replacement employed did not completely restore a normal RMR in obese subjects on a very low energy diet, in spite of elevating serum thyroid hormone concentrations slightly above weight-maintenance levels.